Molecules in focus - The high mobility group protein, HMGI-C
Molecules in focus - The high mobility group protein, HMGI-C
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DOI：
10.1016/s1357-2725(98)00016-8
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发表时间：
1998-07-01
影响因子：
4
通讯作者：
Goodwin, G
中科院分区：
文献类型：
--
作者：
Goodwin, G
HMGI-C是一种核磷蛋白，含有三个短的DNA结合结构域（AT-钩）和一个高度酸性的C-末端。最近的三个观察结果刺激了对该蛋白的兴趣：该基因的表达受细胞周期调节，该基因在许多间充质来源的肿瘤中重排，并且具有两个HMGI-C等位基因被破坏的小鼠表现出侏儒表型。这些观察结果表明HMGI-C在细胞生长中的作用，更具体地说，在胎儿生长期间，因为该蛋白通常仅在胚胎组织中表达。HMGI-C蛋白可能作为一种结构转录因子，调节一种或多种控制胚胎细胞生长的基因的表达。由于HMGI-C与富含AT的DNA的小沟结合，这种相互作用可能是小沟化疗剂在治疗表达重排基因的肉瘤中的靶点。(C)1998爱思唯尔科技有限公司版权所有。
HMGI-C is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. Interest in the protein has recently been stimulated by three observations: the expression of the gene is cell-cycle regulated, the gene is rearranged in a number of tumours of mesenchymal origin and mice that have both HMGI-C alleles disrupted exhibit the pygmy phenotype, These observations suggest a role for HMGI-C in cell growth, more specifically, during foetal growth since the protein is normally only expressed in embryonic tissues. It is likely that the HMGI-C protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGI-C binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (C) 1998 Elsevier Science Ltd. All rights reserved.