Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age
Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age
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DOI：
10.1002/neu.10215
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发表时间：
2003-07-01
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影响因子：
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通讯作者：
Ferrús, A
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文献类型：
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作者：
Devaud, JM;Acebes, A;Ferrús, A
几个全变态昆虫物种的嗅觉系统在影像羽化后经历了解剖学上的变化，这些变化发生在变态过程中。与此同时，气味体验和学习表现也随着年龄的增长而发展。在这里，我们分析成年雌性果蝇的情况。触角叶（AL）的突触发生始于蛹后期，并持续到成虫生命的最初几天，与此同时，对气味的行为反应也成熟了。个体嗅肾小球（DM6、DM2和V）在成年后第1 - 12天表现出特定的生长模式。适应性实验表明，经验可以在结构和功能上改变嗅觉通路。与这种形式的非联想学习相关的变化似乎发生在关键年龄。在成年后2-5天暴露于苯甲醛，而不是在8-11天暴露于苯甲醛，会导致行为适应以及肾小球DM2和V的结构变化。由杜奇和芜菁甘蓝突变体引起的细胞内cAMP水平的改变，至少在发育第6天不会影响肾小球大小的正常变化，但它们会阻止由经验引起的肾小球大小的正常变化，从而建立了内源性肾小球变化与环境性肾小球变化之间的分子差异。综上所述，这些数据证明了年轻成年果蝇嗅觉通路中的印记样现象，并说明了其肾小球特异性动力学。(C) 2003 Wiley期刊有限公司
The olfactory system of several holometabolous insect species undergoes anatomical changes after eclosion of the imago, following those occurring during metamorphosis. In parallel, odor experience and learning performance also evolve with age. Here, we analyze the case of adult Drosophila females.Synaptogenesis in the antennal lobe (AL) starts in late pupa and continues during the first days of adult life, at the same time as the behavioral response to odors matures. Individual olfactory glomeruli (DM6, DM2, and V) display specific growth patterns between days 1 and 12 of adult life. Experience can modify the olfactory pathway both structurally and functionally as shown by adaptation experiments. The modifications associated with this form of nonassociative learning seem to take place at a critical age. Exposure to benzaldehyde at days 2-5 of adult life, but not at 8-11, causes behavioral adaptation as well as structural changes in DM2 and V glomeruli. Altered levels in intracellular cAMP, caused by dunce and rutabaga mutants, do not affect the normal changes in glomerular size, at least at day 6 of development, but they prevent those elicited by experience, establishing a molecular difference between glomerular changes of intrinsic versus environmental origin. Taken together, these data demonstrate an imprinting-like phenomenon in the olfactory pathway of young Drosophila adults, and illustrate its glomerulus-specific dynamics. (C) 2003 Wiley Periodicals, Inc.