Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute
Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute
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DOI：
10.1016/s0142-9612(98)00061-1
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发表时间：
1998-08-01
期刊：
影响因子：
14
通讯作者：
Daculsi, G
中科院分区：
文献类型：
--
作者：
Daculsi, G
磷酸钙陶瓷及其他相关骨移植生物材料的发展涉及到更好地控制生物材料的吸收和骨替代过程。提出了双相磷酸钙陶瓷（BCP）的生物活性概念。获得了更稳定的HA和更可溶性的TCP的最佳平衡，以控制体内的逐渐溶解，在将钙和磷酸盐离子释放到生物培养基中时，播下新骨的形成。描述了骨/材料界面以及在这种动态界面的发展过程中发生的事件，如细胞反应、材料的生物降解或生物吸收以及它们向碳酸盐羟基磷灰石（CHA）的转化。在散装样品、种植体涂层和可注射骨替代物（IBS）中均观察到这些过程。1998爱思唯尔科学有限公司版权所有。
The development of calcium phosphate ceramics and other related biomaterials for bone graft involved a better control of the process of biomaterials resorption and bone substitution. The bioactive concept was developed for biphasic calcium phosphate ceramics (BCP). An optimum balance of the more stable phase of HA and more soluble TCP was obtained for controlling gradual dissolution in the body, seeding new bone formation as it releases calcium and phosphate ions into the biological medium. The bone/material interface and the events occurring in the development of this dynamic interface such as cellular response, biodegradation or bioresorption of the materials and their transformation to carbonate hydroxyapatite (CHA) were described. These processes were observed in both bulk samples, implant coating and injectable bone substitute (IBS). (C) 1998 Elsevier Science Ltd. All rights reserved.