Alzheimer's Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention.
Alzheimer's Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention.
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DOI：
10.3233/jad-160388
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发表时间：
2016-06-27
期刊：
影响因子：
--
通讯作者：
Allen HB
中科院分区：
文献类型：
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作者：
Allen HB
阿尔茨海默病（AD）是一种由螺旋体引起的传染病，这些螺旋体形成生物膜，吸引先天免疫系统。先天免疫系统第一反应者 Toll 样受体 2 会产生 NF-κB 和 TNF-α，它们试图杀死生物膜中的螺旋体，但无法穿透“粘液”。 NF-κB 还负责产生淀粉样蛋白 -β (Aβ)，而淀粉样蛋白 -β 本身具有抗菌作用。 Aβ也不能穿透生物膜，其积累会导致大脑神经回路的破坏。概述了青霉素治疗（如三期梅毒，AD 的比较）；方案中可能需要添加生物膜分散剂。
Alzheimer’s disease (AD) is an infectious disease caused by spirochetes, and these spirochetes form biofilms, which attract the innate immune system. The innate immune system first responder, Toll-like receptor 2, generates both NF-κB and TNF-α which try to kill the spirochetes in the biofilm, but cannot penetrate the “slime”. NF-κB is also responsible for the generation of amyloid-β (Aβ) which itself is anti-microbial. Aβ cannot penetrate the biofilm either, and its accumulation leads to destruction of the cerebral neurocircuitry. Treatment with penicillin (as in tertiary syphilis, the comparator to AD) is outlined; a biofilm dispersing agent may need to be added to the protocol.