Expression of T cell differentiation antigens and Ia on rat cytotoxic T lymphocytes.
Expression of T cell differentiation antigens and Ia on rat cytotoxic T lymphocytes.
复制标题
T细胞分化抗原和Ia在大鼠细胞毒性T淋巴细胞上的表达。
DOI：
10.4049/jimmunol.128.2.580
复制
发表时间：
1982
影响因子：
4.4
通讯作者：
T. Strom
中科院分区：
文献类型：
--
作者：
A. Duarte;C. Carpenter;T. Strom
Study of lymphocyte subsets has been facilitated by the detection of various surface markers that are related to distinct functions. We have explored the use of affinity methods for separation of large quantities (10(8)) of rat cells and used this technique to identify surface markers of cytotoxic T lymphocytes. Splenocytes from animals bearing skin allografts for 7 days were depleted of B cells and were separated into T cell subsets by using W3/25 and OX8 monoclonal antibodies, which mark two nonoverlapping populations of peripheral T cells. Our results demonstrate that the cytotoxic T cells are W3/25- and OX8+. They also bear minimal or no Ag-F alloantigen, a peripheral T cell marker, and they express Ia-like products analogous to those of the mouse I-A subregion but not of the I-E/C subregion.
