The measurement and analysis of age-related changes in Caenorhabditis elegans.
The measurement and analysis of age-related changes in Caenorhabditis elegans.
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DOI：
10.1895/wormbook.1.137.1
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发表时间：
2008-01-24
期刊：
影响因子：
--
通讯作者：
Kornfeld, Kerry
中科院分区：
文献类型：
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作者：
Collins, James J;Huang, Cheng;Kornfeld, Kerry
衰老的特征是组织组织和功能的进行性退行性变化，从而增加死亡的可能性。衰老研究的主要目标包括阐明导致退行性变化的一系列事件，并分析调节这些变化的环境和遗传因素。衰老机制研究的基础是准确和精确地描述与年龄相关的变化，因为这些描述定义了衰老表型。在此，我们回顾了描述秀丽隐杆线虫年龄相关变化的研究，包括行为等综合功能的测量，组织组织的微观分析和大分子的生化研究。本文描述了影响这些变化的遗传和环境因素，并讨论了分析不同年龄相关变化之间关系的研究。总之，这些研究为秀丽隐杆线虫的衰老提供了基本的见解，这可能与其他动物的衰老有关。
Aging is characterized by progressive degenerative changes in tissue organization and function that increase the probability of mortality. Major goals of aging research include elucidating the series of events that cause degenerative changes and analyzing environmental and genetic factors that modulate these changes. The basis for mechanistic studies of aging are accurate and precise descriptions of age-related changes, since these descriptions define the aging phenotype. Here we review studies that describe age-related changes in C. elegans including measurements of integrated functions such as behavior, microscopic analyses of tissue organization, and biochemical studies of macromolecules. Genetic and environmental factors that influence these changes are described, and studies that analyze the relationships between different age-related changes are discussed. Together these studies provide fundamental insights into aging in C. elegans that may be relevant to aging in other animals.