Epidural Corticosteroid Injections for Sciatica
Epidural Corticosteroid Injections for Sciatica
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DOI：
10.1097/brs.0000000000003651
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发表时间：
2020-11-01
期刊：
影响因子：
3
通讯作者：
Pinto, Rafael Z.
中科院分区：
文献类型：
--
作者：
Oliveira, Crystian B.;Maher, Christopher G.;Pinto, Rafael Z.
Study Design. Systematic with meta-analysisObjectives. The aim of this study was to investigate the efficacy and safety of epidural corticosteroid injections compared with placebo injection in reducing leg pain and disability in patients with sciatica.Summary of Background Data. Conservative treatments, including pharmacological and nonpharmacological treatments, are typically the first treatment options for sciatica but the evidence to support their use is limited. The overall quality of evidence found by previous systematic reviews varies between moderate and high, which suggests that future trials may change the conclusions. New placebo-controlled randomized trials have been published recently which highlights the importance of an updated systematic review.Methods. The searches were performed without language restrictions in the following databases from 2012 to 25 September 2019: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, PubMed, Embase, CINAHL, PsycINFO, International Pharmaceutical Abstracts, and trial registers. We included placebo-controlled randomized trials investigating epidural corticosteroid injections in patients with sciatica. The primary outcomes were leg pain intensity and disability. The secondary outcomes were adverse events, overall pain, and back pain intensity. We grouped similar trials according to outcome measures and their respective follow-up time points. Short-term follow-up (>2 weeks but
