Polydopamine Coated Selenide Molybdenum: A New Photothermal Nanocarrier for Highly Effective Chemo-Photothermal Synergistic Therapy
Polydopamine Coated Selenide Molybdenum: A New Photothermal Nanocarrier for Highly Effective Chemo-Photothermal Synergistic Therapy
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聚多巴胺涂层硒化钼：一种用于高效化学光热协同治疗的新型光热纳米载体
DOI：
10.1021/acsbiomaterials.6b00416
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发表时间：
2016-11-01
影响因子：
5.8
通讯作者：
Jiang, Xiue
中科院分区：
文献类型：
--
作者：
Wang, Chao;Bai, Jing;Jiang, Xiue
近年来，二维过渡金属二硫属化合物（TMDCs）在生物医学领域得到了广泛的研究。在本文中，我们开发了一种新的光热纳米载体基于聚多巴胺涂层硒化钼（MoSe2@PDA）作为一种有效的纳米载体负载抗癌药物阿霉素（MoSe 2 @PDA-Dox）。将PDA偶联到MoSe 2纳米片表面，不仅可以增强MoSe 2纳米片的光热效应，降低其细胞毒性，而且可以为Dox的负载提供锚点。所得MoSe2@PDA纳米复合材料具有良好的生物相容性、良好的稳定性和高的光热转换效率。随后装载抗癌药物阿霉素（Dox）产生具有pH和热响应性药物释放的有效治疗剂。体内实验显示对肿瘤组织的强烈损伤，几乎完全杀死肿瘤细胞。因此，MoSe 2 @PDA-Dox纳米复合材料可能在未来的癌症治疗中发挥关键作用。我们的工作揭示了将化学疗法和光热疗法相结合以实现肿瘤治疗的协同效应的巨大前景。
Recently, two-dimensional transition metal dichalcogenides (TMDCs) have been widely studied in biomedicine. In this article, we developed a new photothermal nanocarrier based on polydopamine coated selenide molybdenum (MoSe2@PDA) as an effective nanocarrier for loading anticancer drug doxorubicin (MoSe2@PDA-Dox). Conjugation of PDA onto the surface of MoSe2 nanosheets can not only enhance the photothermal effect of MoSe2 nanosheets and decrease its cytotoxicity but also provide anchor points for loading Dox. The resulting MoSe2@PDA nanocomposites exhibit good biocompatibility, good stability, and high photothermal conversion efficiency. The subsequent loading of anticancer drug doxorubicin (Dox) creates an efficient therapeutic agent with pH- and heat-responsive drug release. An in vivo experiment shows strong damage to tumor tissue, killing the tumor cell almost thoroughly. On that account, the MoSe2@PDA-Dox nanocomposites may play a key role in cancer therapy in the future. Our work reveals the great promise of combing chemical and photothermal therapy to realize a synergistic effect for tumor treatment.