The effect of depression on return to drinking - A prospective study
The effect of depression on return to drinking - A prospective study
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DOI：
10.1001/archpsyc.55.3.259
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发表时间：
1998-03-01
影响因子：
--
通讯作者：
Michael, J
中科院分区：
文献类型：
--
作者：
Greenfield, SF;Weiss, RD;Michael, J
背景：抑郁对酒依赖患者重新饮酒的影响是有争议的。从1993年2月1日至1996年4月15日，我们连续招募了40名女性和61名男性因酒依赖而住院，并每月随访1年，以评估抑郁对饮酒结果的影响。方法：我们在住院期间和出院后每月进行结构化访谈，以确定治疗开始时抑郁是否影响再次饮酒的可能性，以及这种影响是否存在性别差异。结果：住院时确诊的当前抑郁症与首次饮酒的风险比2.03(95%可信区间1.28~3.21；P=0.003)和复发相关(风险比2.12；95%可信区间1.32~3.39；P=0.002)。在这一效应上，女性和男性之间没有显著差异。Beck抑郁量表测量的抑郁症状不能预测女性或男性首次饮酒或复发的时间。结论：目前因酒精依赖而进入住院治疗的严重抑郁症预示着女性和男性首次饮酒和复发的时间较短。我们的结果不同于早先的报道，即男性和女性在抑郁对重新饮酒的影响方面存在差异。
Background: The effect of depression on return to drinking among individuals with alcohol dependence is controversial. From February 1, 1993, to April 15, 1996, we consecutively recruited 40 women and 61 men hospitalized for alcohol dependence and followed them up monthly for 1 year to assess the effect of depression on drinking outcomes.Methods: We conducted structured interviews during hospitalization and monthly following discharge for 1 year to determine whether depression at treatment entry affected the likelihood of return to drinking and whether this effect differed between sexes. Using survival analysis, we examined the effect of depressive symptoms and a diagnosis of current major depression at treatment entry on times to first drink and relapse during follow-up.Results: A diagnosis of current major depression at the time of hospitalization was associated with shorter times to first drink (hazard ratio, 2.03; 95% confidence interval [CI], 1.28-3.21; P=.003) and relapse (hazard ratio, 2.12; 95% CI, 1.32-3.39; P=.002). There was no significant difference between women and men in this effect. Depressive symptoms as measured by the Beck Depression Inventory did not predict time to first drink or relapse in women or men.Conclusions: A diagnosis Of current major depression at entry into inpatient treatment for alcohol dependence predicted shorter times to first drink and relapse in women and men. Our results differ from earlier reports that men and women differ in the effect of depression on return to drinking.