CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth
CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth
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DOI：
10.1128/jvi.00375-13
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发表时间：
2013-05-01
影响因子：
5.4
通讯作者：
Usherwood, Edward J.
中科院分区：
文献类型：
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作者：
Liang, Xiaozhan;Crepeau, Rebecca L.;Usherwood, Edward J.
关于EB病毒转化的细胞的T细胞识别已经有了广泛的研究，然而，关于伽马-2疱疹病毒永生化的B细胞的识别却知之甚少。在此，我们证明了由小鼠伽马疱疹病毒68(MHV-68，Gamma HV-68)永生化的B细胞在体内可以被CD4或CD8T细胞控制。我们提出了CD4和CD8T细胞直接识别感染的B细胞的证据。这些数据将有助于开发抗击伽马-2疱疹病毒相关疾病的免疫治疗方法。
There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, gamma HV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.