Prevalence and correlates of lower extremity arterial disease in elderly women.
Prevalence and correlates of lower extremity arterial disease in elderly women.
复制标题
老年女性下肢动脉疾病的患病率和相关性。
DOI：
10.1093/oxfordjournals.aje.a116709
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发表时间：
1993
影响因子：
5
通讯作者：
Hulley,SB
中科院分区：
文献类型：
--
作者：
Vogt,MT;Cauley,JA;Kuller,LH;Hulley,SB
尽管75岁以上人群中有15-20%发生下肢动脉疾病，但对女性患者的病因知之甚少。在这项横断面研究中，涉及1,601名健康老年女性（平均年龄71岁，范围65-93岁），通过测量双侧肱动脉和踝动脉压力，非侵入性评估下肢动脉疾病的发生率。患病率从65-69岁人群的2.9%到80岁或以上人群的15.5%不等。大约20%的患者有跛行症状。年龄、收缩压和当前吸烟状况是动脉疾病的强独立危险因素;关节炎史、使用非噻嗪类利尿剂、当前饮用咖啡和上身肥胖也是独立相关因素。目前和以前吸烟者的包年数以及目前吸烟者每天使用的香烟数量与疾病呈剂量反应关系。目前吸烟的人群归因风险为26%。有症状的动脉疾病的主要相关因素是目前吸烟和收缩压。结论老年女性下肢动脉疾病的主要危险因素与男性相似。预防工作应侧重于戒烟和高血压的管理。
Although lower extremity arterial disease occurs in 15–20% of the population over the age of 75 years, little is known about the etiology of the disease in women. In this cross-sectional study involving 1,601 healthy elderly women (mean age, 71 years; range, 65–93 years), the occurrence of lower extremity arterial disease was assessed noninvasively by measuring brachial and ankle pressures bilaterally. Disease prevalence ranged from 2.9% in those aged 65–69 years to 15.5% in those aged 80 years or older. Approximately 20% of those with disease had symptoms of claudication. Age, systolic blood pressure, and current smoking status were strong independent risk factors for arterial disease; a history of arthritis, use of nonthiazide diuretics, current coffee drinking, and upper body obesity were also independent correlates. The number of pack-years in current and former smokers and the number of cigarettes per day used by current smokers showed a dose-response relation with disease. The population attributable risk for current smoking was 26%. The major correlates for symptomatic arterial disease were current smoking and systolic blood pressure. It is concluded that the major risk factors for lower extremity arterial disease in elderly women are similar to those in men. Preventive efforts should focus on smoking cessation and management of hypertension.