Roles of α- and β-estrogen receptors in mouse social recognition memory: Effects of gender and the estrous cycle
Roles of α- and β-estrogen receptors in mouse social recognition memory: Effects of gender and the estrous cycle
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DOI：
10.1016/j.yhbeh.2010.10.016
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发表时间：
2011-01-01
影响因子：
3.5
通讯作者：
Kendrick, K. M.
中科院分区：
文献类型：
--
作者：
Sanchez-Andrade, G.;Kendrick, K. M.
在女性卵巢周期中，确定性别和自然激素变化对认知功能的影响往往被证明是困难的。在这里，我们已经调查了这种影响的形成和长期（24小时）的社会识别记忆的小鼠连同各自参与的α-和β-雌激素受体使用α-和β-雌激素受体基因敲除小鼠和野生型对照。野生型动物的结果表明，虽然雌性动物在其卵巢周期的所有阶段都成功地形成了习惯化/去习惯化范式的背景下的记忆，但只有当学习发生在发情前期（雌激素水平最高时）时，它才能在24小时后保留下来。在α-受体敲除小鼠（没有卵巢周期）中，这种社会识别记忆的形成和维持都受到损害，而β-受体敲除小鼠没有表现出明显的缺陷，并在24小时内表现出相同的发情前期依赖性记忆保留。为了研究可能的性别差异，还测试了雄性α-和β-雌激素受体敲除小鼠，除了α-受体敲除小鼠具有正常的记忆形成并且仅表现出24小时的保持缺陷之外，其显示出与雌性相似的效果。这表明在这项任务中，女性对α受体表达的记忆形成有更大的依赖性。由于非特定的动机和注意力方面的任务是不受影响的，我们的研究结果表明，一般α-受体依赖性促进记忆的形成，雌激素以及增强长期保留在发情前期。结果进行了讨论的两个雌激素受体的不同作用，神经基板参与和推定的相互作用与催产素。(C)2010年爱思唯尔公司All rights reserved.
Establishing clear effects of gender and natural hormonal changes during female ovarian cycles on cognitive function has often proved difficult. Here we have investigated such effects on the formation and long-term (24 h) maintenance of social recognition memory in mice together with the respective involvement of alpha- and beta-estrogen receptors using alpha- and beta-estrogen receptor knockout mice and wildtype controls. Results in wildtype animals showed that while females successfully formed a memory in the context of a habituation/dishabituation paradigm at all stages of their ovarian cycle, only when learning occurred during proestrus (when estrogen levels are highest) was it retained after 24 h. In alpha-receptor knockout mice (which showed no ovarian cycles) both formation and maintenance of this social recognition memory were impaired, whereas beta-receptor knockouts showed no significant deficits and exhibited the same proestrus-dependent retention of memory at 24 h. To investigate possible sex differences, male alpha- and beta-estrogen receptor knockout mice were also tested and showed similar effects to females excepting that alpha-receptor knockouts had normal memory formation and only exhibited a 24 h retention deficit. This indicates a greater dependence in females on alpha-receptor expression for memory formation in this task. Since non-specific motivational and attentional aspects of the task were unaffected, our findings suggest a general alpha-receptor dependent facilitation of memory formation by estrogen as well as an enhanced long-term retention during proestrus. Results are discussed in terms of the differential roles of the two estrogen receptors, the neural substrates involved and putative interactions with oxytocin. (C) 2010 Elsevier Inc. All rights reserved.