THE EFFECTS OF SENSORY DENERVATION ON THE RESPONSES OF THE RABBIT EYE TO PROSTAGLANDIN E1, BRADYKININ AND SUBSTANCE P
THE EFFECTS OF SENSORY DENERVATION ON THE RESPONSES OF THE RABBIT EYE TO PROSTAGLANDIN E1, BRADYKININ AND SUBSTANCE P
复制标题
感觉去神经支配对兔眼对前列腺素 E1、缓激肽和 P 物质反应的影响
DOI：
10.1111/j.1476-5381.1980.tb07040.x
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发表时间：
1980
影响因子：
7.3
通讯作者：
B. Hammond
中科院分区：
文献类型：
--
作者：
J. M. Butler;B. Hammond
[1]家兔第五脑神经的透热破坏后6 ~ 8天，前房内给予辣椒素、缓激肽和前列腺素E1的眼压升高和缩瞳反应大大降低或完全消失。对P物质的答复没有取消。（2）电凝后36 h，神经对化学刺激物仍有反应，推测反应的表现依赖于功能性感觉神经末梢，而不依赖于中枢联系。3提示前列腺素E_1和缓激肽直接作用于感觉神经末梢，轴突反射增强了这种反应的传播。4鉴于P物质在失神经支配的眼睛中诱导瞳孔缩小的能力，推测其作用不是通过感觉神经介导的。5化学刺激或逆向刺激后感觉神经末梢释放的介质可能与P物质在缩瞳效应方面的作用方式相同。6合成物质P仅在诱导最大缩瞳反应的剂量下才会产生高眼压。这可能是一个准入问题，也可能是与内生调解人部分相似的问题。
1 Six to eight days after diathermic destruction of the fifth cranial nerve in the rabbit, the ocular hypertensive and miotic responses to intracameral administration of capsaicin, bradykinin, and prostaglandin E1 were greatly reduced or completely abolished. The response to substance P was not abolished. 2 A response could still be obtained to chemical irritants 36 h after coagulation of the nerve and it is deduced that manifestation of the response is dependent upon functional sensory nerve terminals, and is independent of central connections. 3 It is suggested that prostaglandin E1 and bradykinin act directly upon the sensory nerve endings and that propagation of the response is augmented by axon reflex. 4 In view of the ability of substance P to induce miosis in the denervated eyes, it is presumed that its actions are not mediated via sensory nerves. 5 It is considered possible that the mediator(s) released from sensory nerve endings after chemical irritation or antidromic stimulation may act in the same way as substance P with regard to the miotic effect. 6 Synthetic substance P will only produce ocular hypertension in doses which induce a maximal miotic response. This may either be a question of access or a partial resemblance to the endogenous mediator.