Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
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DOI：
10.1126/science.abb2401
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发表时间：
2020-07-31
期刊：
影响因子：
56.9
通讯作者：
Huttner, Wieland B.
中科院分区：
文献类型：
--
作者：
Heide, Michael;Haffner, Christiane;Huttner, Wieland B.
新皮层在哺乳动物进化过程中扩大了。在发育中的小鼠和雪貂新皮质中的过表达研究表明，人类特异性基因ARHGAP 11 B与新皮质扩张有关，但与灵长类进化的相关性尚不清楚。在这里，我们提供了ARHGAP 11B导致灵长类动物新皮层扩张的功能证据。ARHGAP 11 B在基因自身（人类）启动子控制下在普通绒猴胎儿新皮质中表达，增加了绒猴外室下区基底放射状胶质祖细胞的数量，增加了上层神经元的数量，扩大了新皮质，并诱导其折叠。因此，人类特异性ARHGAP 11 B驱动非人灵长类绒猴的发育变化，反映了人类新皮层发育特征的进化变化。
The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that ARHGAP11B causes expansion of the primate neocortex. ARHGAP11B expressed in fetal neocortex of the common marmoset under control of the gene's own (human) promoter increased the numbers of basal radial glia progenitors in the marmoset outer subventricular zone, increased the numbers of upperlayer neurons, enlarged the neocortex, and induced its folding. Thus, the human-specific ARHGAP11B drives changes in development in the nonhuman primate marmoset that reflect the changes in evolution that characterize human neocortical development.