Regulation of subfoveal choroidal blood flow in age-related macular degeneration
Regulation of subfoveal choroidal blood flow in age-related macular degeneration
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DOI：
10.1167/iovs.05-0434
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发表时间：
2006-04-01
影响因子：
4.4
通讯作者：
Soubrane, G
中科院分区：
文献类型：
--
作者：
Pournaras, CJ;Logean, E;Soubrane, G
目的.为了评估中心凹下脉络膜循环调节其血流的能力，以响应健康、老年人或患有新生血管性年龄相关性黄斑变性（AMD）的受试者的眼睛中的眼灌注压的急性增加。采用激光多普勒血流仪（LDF）检测了19名年轻健康志愿者（第1组）、24名老年健康志愿者（第2组）和23名由AMD引起的中心凹下经典新生血管（第3组）在等长运动诱导下的中心凹下脉络膜血流速度（ChBVel）、体积（ChBVel）和流量（ChBF）的变化。组1、组2和组3的等长运动诱导平均眼灌注压（PPm）显著增加，分别为19.5% +/-4.9%、20.2% +/-3.8%和23.2% +/-4.2%（平均95%置信区间）。III组I和2，PPm的增加并没有引起不同LDF参数的平均值的显着变化。然而，在第3组中，ChBF显著增加12.4% +/-5.0%。未发现年龄与青年和老年健康组蹲位结束时LDF参数和PPm的变化之间存在显著相关性。在对等长运动诱导的PPm的所有急性、中度增加的响应中，中心凹下脉络膜血流在年轻人和老年人中表现相似，并且与其在休息时的值没有显著差异。相比之下，在患有新生血管性AMD的患者中，这种流量增加，表明响应于PPm增加的调节改变。
PURPOSE. To assess the capability of the subfoveal choroidal circulation to regulate its blood flow in response to an acute increase in ocular perfusion pressure in the eyes of health), elderly persons or of subjects with neovascular age-related macular degeneration (AMD).METHODS. Changes of subfoveal choroidal blood velocity (ChBVel), volume (ChBVol), and flow (ChBF) induced by isometric exercise were determined using laser Doppler flow-metry (LDF) in 19 young healthy volunteers (group 1), 24 elderly healthy volunteers with mild macular pigment distribution changes (group 2), and 23 subjects with subfoveal classic neovascularization caused by AMD (group 3).RESULTS. Isometric exercise induced significant increases ill mean ocular perfusion pressure (PPm) of 19.5% +/- 4.9%, 20.2% +/- 3.8%, and 23.2% +/- 4.2%, for groups 1, 2, and 3, respectively (mean 95% confidence interval). III groups I and 2, the increase in PPm did not induce significant changes in the mean values of the different LDF parameters. In group 3, however, ChBF increased significantly by 12.4% +/- 5.0%. No significant correlations were found between age and the changes of each of the LDF parameters and of PPm at the end of squatting for the young and elderly healthy groups.CONCLUSIONS. In response to all acute, moderate increase in PPm induced by isometric exercise, subfoveal choroidal blood flow behaves similarly in young and elderly health), persons and is not significantly different from its value at rest. In contrast, in patients with neovascular AMD, this flow increases, indicating altered regulation in response to the increase in PPm.