Structural and functional analyses of bacterial lipopolysaccharides

Structural and functional analyses of bacterial lipopolysaccharides
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DOI:
10.1016/s1286-4579(02)01612-x
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发表时间:
2002-07-01
影响因子:
5.8
通讯作者:
Haeffner-Cavaillon, N
Haeffner-Cavaillon, N
中科院分区:
医学3区
文献类型:
--
作者:
Caroff, M;Karibian, D;Haeffner-Cavaillon, N

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细菌脂多糖(LPS)是受感染宿主体内强大的免疫调节剂,并可能引起内毒素性休克。它们中的大多数具有共同的结构,但从一个属、种和品系到另一个属、种和品系的结构基序有很大差异。先天免疫反应的细胞识别进化上保守的内毒素 LPS 分子模式和结构细节,从而极大地影响它们的反应。 (C) 2002 年科学与医学版 Elsevier SAS。版权所有。
Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and may cause endotoxic shock. Most of them share a common architecture but vary considerably in structural motifs from one genus, species, and strain to another. Cells of the innate immune response recognize evolutionarily conserved LPS molecular patterns of endotoxins and structural details thereby greatly influencing their response. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.