Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells.
Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells.
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DOI：
10.1016/j.drudis.2012.04.002
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发表时间：
2012-09
影响因子：
7.4
通讯作者：
Zhang, Lubo
中科院分区：
文献类型：
--
作者：
Hu, Xiang-Qun;Zhang, Lubo
大电导钙激活钾通道（BKCa）在血管平滑肌细胞中大量表达。BKCa通道的激活导致细胞膜的超极化，这反过来又抵消了血管收缩。因此，BKCa通道在调节血管张力和血压中具有重要作用。BKCa通道的活性受到多种因素的调节。此外，BKCa通道的功能在生理和病理生理条件下都发生改变，例如妊娠、高血压和糖尿病，这对血管张力和血流动力学具有显著影响。因此，改变通道活性和表达的化合物和遗传操作可能具有治疗意义。
Large conductance Ca21-activated K1 (BKCa) channels are abundantly expressed in vascular smooth muscle cells. Activation of BKCa channels leads to hyperpolarization of cell membrane, which in turn counteracts vasoconstriction. Therefore, BKCa channels have an important role in regulation of vascular tone and blood pressure. The activity of BKCa channels is subject to modulation by various factors. Furthermore, the function of BKCa channels are altered in both physiological and pathophysiological conditions, such as pregnancy, hypertension and diabetes, which has dramatic impacts on vascular tone and hemodynamics. Consequently, compounds and genetic manipulation that alter activity and expression of the channel might be of therapeutic interest.
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DOI：
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发表时间：
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影响因子：
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