Secondary generalization in seizures of temporal lobe origin: Ictal EEG pattern in a stereo-EEG study
Secondary generalization in seizures of temporal lobe origin: Ictal EEG pattern in a stereo-EEG study
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DOI：
10.1016/j.yebeh.2009.03.032
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发表时间：
2009-06-01
影响因子：
2.6
通讯作者：
Novak, Zdenek
中科院分区：
文献类型：
--
作者：
Rektor, Ivan;Zakopcan, Jozef;Novak, Zdenek
目的：验证继发性全面性癫痫(SGS)不是真正的全身性发作，而是可能涉及选择性区域的假说。方法：对15例手术患者的20例继发性全身性癫痫(TLE)患者进行了立体脑电(SEEG)记录，研究了从局灶性发作到全面性发作的扩散。电极被分配到额眶、前额叶和颞叶皮质、扣带回、海马体和杏仁核。通过对录像的行为分析确定SGS的发病时间。脑电记录使用Blumenfeld[Blumenfeld H，Rivera M，McNally Ka，Davis K，Spencer DD，Spencer SS]开发的分级标准进行评估。颞叶癫痫的发作期新皮质减慢。神经病学2004：63：1015-21]。结果：扣带回和额眶皮质的癫痫发作等级差异显著，前额叶皮质的癫痫发作等级有显著差异。结论：当累及头部、面部和所有肢体时，继发性泛化的开始并不意味着全脑皮质受累。(C)2009 Elsevier Inc.保留所有权利。
Objective: We tested the hypothesis that secondary generalized seizures (SGS) are not truly generalized and may involve selective regions.Methods: The spread from focal to generalized seizures in temporal lobe epilepsy (TLE) was studied in 20 SGS recorded via stereo-EEG (SEEG) in 15 candidates for surgery. Electrodes were assigned to fronto-orbital, prefrontal, and temporal cortex, cingulate, hippocampus, and amygdala. The onset of SGS was ascertained by behavioral analysis of the video recordings. EEG recordings were evaluated using the rating scale developed by Blumenfeld [Blumenfeld H, Rivera M, McNally KA, Davis K, Spencer DD, Spencer SS. Ictal neocortical slowing in temporal lobe epilepsy. Neurology 2004:63:1015-21]. The seizure rating in each region was compared with the rating in the hippocampus.Results: Ranking significantly differed in the cingulate and fronto-orbital cortex; there was a trend toward significance in the prefrontal cortex. In these regions, slow activity dominated.Conclusion: The onset of secondary generalization, when the head, face and all limbs are involved, does not implicate global cortical involvement. (C) 2009 Elsevier Inc. All rights reserved.