The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: A magnetic resonance imaging tagging study
The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: A magnetic resonance imaging tagging study
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DOI：
10.1016/j.jtcvs.2005.07.065
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发表时间：
2006-03-01
影响因子：
6
通讯作者：
Ratcliffe, MB
中科院分区：
文献类型：
--
作者：
Guccione, JM;Walker, JC;Ratcliffe, MB
目的：虽然左室室壁瘤的修补术已被广泛研究，但其对局部心室功能的影响仍不清楚。本研究的主要目标是量化的影响，前心尖动脉瘤折叠收缩变形在noninfarcted相邻（边界区）和远程左心室regions.Methods：8羊进行前心尖心肌梗死（左心室质量的25%）。10周后，动物接受动脉瘤折叠术。手术后2周和6周，动物接受磁共振成像，在多个短轴和长轴切片中进行组织标记。进行了全三维应变分析。所有6个收缩末期应变分量进行了比较，在中壁的边缘区的动脉瘤或修复，并在区域1 cm，2 cm，和3 cm以下valves.Results：周向缩短进行性增加，从折叠前到折叠后2周到6周后折叠向边缘区。对周向缩短的影响在前壁和间隔中最明显。折叠术后2 ~ 6周变化最大（前壁从4.3%~ 11.3%，P
Objectives: Although repair of left ventricular aneurysm has been extensively studied, its effect on regional ventricular function remains unclear. The primary goal of this study was to quantify the effect of anteroapical aneurysm plication on systolic deformation in noninfarcted adjacent (border zone) and remote left ventricular regions in sheep.Methods: Eight sheep underwent anteroapical myocardial infarction (25% of left ventricular mass). Ten weeks later, animals underwent aneurysm plication. Two and 6 weeks after this operation, animals underwent magnetic resonance imaging with tissue tagging in multiple short-axis and long-axis slices. Fully 3-dimensional strain analyses were performed. All 6 end-systolic strain components were compared at midwall in the border zone of the aneurysm or repair and in regions 1 cm, 2 cm, and 3 cm below the valves.Results: Circumferential shortening progressively increases from before plication to 2 weeks after plication to 6 weeks after plication toward the border zone. The effect on circumferential shortening is most pronounced in the anterior wall and septum. The biggest change is from 2 to 6 weeks after plication (from 4.3% to 11.3% in anterior wall, P