Paracetamol administration is associated with hypotension in the critically ill.
Paracetamol administration is associated with hypotension in the critically ill.
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DOI：
10.1016/s1036-7314(97)70414-4
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发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Torda, T A
中科院分区：
文献类型：
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作者：
Boyle, M;Hundy, S;Torda, T A
亨利王子医院重症监护室（ICU）的护理人员曾报道过对乙酰氨基酚给药与重症监护患者相对低血压之间的相关性。因此，进行了一项观察性研究，以确定扑热息痛给药与血压变化之间是否存在时间相关性。口服或通过饲管给予1 g对乙酰氨基酚。在扑热息痛给药前30分钟、给药时记录血压，然后在给药后第1小时每隔15分钟记录一次，第2小时每隔半小时记录一次。使用重复测量ANOVA对来自37个个体的数据进行的分析显示，在观察期内，收缩期动脉压（SAP）和平均动脉压（MAP）显著降低（两者均为p < 0.0001）。SAP和MAP分别平均下降约10%和7%，最大福尔斯分别为36%和34%。对乙酰氨基酚给药可能适用于控制危重患者的发热，从而降低需氧量。然而，这必须与导致血压显著下降的可能性相平衡。
An association between the administration of paracetamol and relative hypotension in critically ill intensive care patients has been reported anecdotally by nursing staff working in the Intensive Care Unit (ICU) of Prince Henry Hospital. An observational study was therefore undertaken, to determine whether there is a temporal association between the administration of paracetamol and changes in blood pressure. A dose of 1 gram of paracetamol was administered orally or by feeding tube. Blood pressure was recorded 30 minutes prior to paracetamol administration, at the time of administration and then at 15-minute intervals for the first hour and at half-hour intervals for the second hour after administration. Analysis of data from 37 individuals using a repeated measures ANOVA showed that systolic arterial pressure (SAP) and mean arterial pressure (MAP) were reduced significantly over the observation period (p < 0.0001 for both). SAP and MAP fell by an average of approximately 10 and 7 per cent respectively, with maximum falls of 36 and 34 per cent respectively. Paracetamol administration may be indicated for the control of fever in critically ill patients, thereby reducing oxygen demand. However, this must be balanced against the possibility of causing a significant fall in blood pressure.