LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.
LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation.
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亚临床甲状腺功能减退症患者的 LDL 显示脂质过氧化增加。
DOI：
10.1186/s12944-015-0092-4
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发表时间：
2015-08-25
影响因子：
4.5
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Zha K;Zuo C;Wang A;Zhang B;Zhang Y;Wang B;Wang Y;Zhao J;Gao L;Xu C
基于人群的研究表明，亚临床甲状腺功能减退（SCH）是动脉粥样硬化的独立危险因素（OR = 1.9）。脂质过氧化在动脉粥样硬化的发生发展中也起着重要的作用。在这项研究中，我们旨在通过测定血浆和低密度脂蛋白（LDL）中羟基十八碳二烯酸（HODEs）和羟基二十碳四烯酸（HETEs）的浓度来评估SCH患者的氧化应激。对象和方法：采用液相色谱-电喷雾电离-质谱联用技术检测甲状腺功能正常（n= 10）、轻度SCH（4.5≤TSH <10 mU/L,n= 10）和重度SCH （TSH≥10 mU/L,n= 10）患者LDL和血浆中HODEs和HETEs的浓度。然后，我们探讨了LDL氧化，TSH水平和颈动脉内膜-中膜厚度（IMT）之间的关系，IMT是亚临床动脉粥样硬化的生物标志物。结果血清LDL-C水平和平均imt水平显著高于甲状腺功能正常组（p< 0.05）。重度SCH患者的HODE和HETE浓度明显高于正常甲状腺功能组，而轻度SCH组与正常甲状腺功能组之间无显著差异。在所有受试者中，校正混杂因素后TSH与mean-IMT呈显著的线性正相关（r = 0.480,p= 0.018）。LDL 9-HODE （r = 0.376,p= 0.041）、13-HODE （r = 0.447,p= 0.013）与TSH呈线性正相关。增厚IMT组LDL中hode （9-HODE和13-HODE）浓度明显高于正常IMT组（p分别为0.017和0.015）。LDL的HODEs也与平均imt呈正相关。结论急性肝功能亢进患者的脂质过氧化水平高于甲状腺功能正常的患者，提示急性肝功能亢进引起的血脂质和定量变化可能增加动脉粥样硬化的风险。
BackgroundPopulation-based studies have demonstrated that subclinical hypothyroidism (SCH) is an independent risk factor for atherosclerosis (OR = 1.9). However, this connection cannot be entirely explained by dyslipidemia accompanied by SCH. Lipid peroxidation also plays an important role in the development of atherosclerosis. In this study, we aimed to evaluate oxidative stress in SCH patients, as measured according to concentrations of hydroxy-octadecadienoic acids (HODEs) and hydroxy-eicosatetraenoic acids (HETEs) in both plasma and low density lipoproteins (LDL).Subjects and methodsThe concentrations of HODEs and HETEs in both LDL and plasma were examined in euthyroid (n= 10), mild SCH (4.5 ≤ TSH <10 mU/L,n= 10), and significant SCH (TSH ≥ 10 mU/L,n= 10) subjects, using a liquid chromatograph-electrospray ionization- mass spectrometer. Then, we explored the relationship among LDL oxidation, TSH levels, and carotid intima-media thickness (IMT), a biomarker of subclinical atherosclerosis.ResultsSerum LDL-C levels and mean-IMT in the significant SCH group were higher than in the euthyroid group (p< 0.05). The HODE and HETE concentrations clearly increased in the significant SCH patients compared with the euthyroid subjects, but there was no difference between the mild SCH and euthyroid groups. Among all subjects, linear and significant positive correlations were identified between TSH and mean-IMT after adjustment for confounding factors (r = 0.480,p= 0.018). Both 9-HODE (r = 0.376,p= 0.041) and 13-HODE (r = 0.447,p= 0.013) in LDL were linearly and positively correlated with TSH. The concentrations of HODEs (both 9-HODE and 13-HODE) in LDL were much higher in the thickened IMT group than in the normal IMT group (p= 0.017 and 0.015, respectively). HODEs in LDL were also positively associated with mean-IMT.ConclusionsOur findings showed that lipid peroxidation was higher in the significant SCH patients than in the euthyroid subjects, which suggested that qualitative as well as quantitative changes in serum lipids resulting from SCH may add to atherosclerosis risk.