Alachalasins A-G, new cytochalasins from the fungus Stachybotrys charatum
Alachalasins A-G, new cytochalasins from the fungus Stachybotrys charatum
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DOI：
10.1016/j.bmc.2007.11.042
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
--
作者：
Zhang, Yonggang;Tian, Renrong;Che, Yongsheng
Alachalasins A-G(1-7)是七种新的细胞松弛素型代谢产物，是从一株水苏子的培养物中分离得到的。这些化合物的结构主要是通过分析它们的核磁共振波谱数据确定的，并用改进的Mosher方法指定了1的绝对构型。Alachalasin A(1)在C8166细胞中表现出抑制HIV-1(LAI)复制的作用，其EC50为8-01 mU M，Alachalasin D(4)和G(7)具有一定的抗菌活性。(C)2007爱思唯尔有限公司。保留所有权利。
Alachalasins A-G (1-7), seven new cytochalasin-type of metabolites, have been isolated from cultures of an isolate of Stachybotrys charatum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data, and the absolute configuration of 1 was assigned by application of the modified Mosher method. Alachalasin A (1) displayed inhibitory effect on HIV-1(LAI) replication in C8166 cells with an EC50 Of 8-01 mu M; alachalasins D (4) and G (7) showed modest antimicrobial activity. (C) 2007 Elsevier Ltd. All rights reserved.