The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area
The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area
复制标题
DOI：
10.1111/liv.12186
复制
发表时间：
2013-08-01
影响因子：
6.7
通讯作者：
Kim, Hyun Young
中科院分区：
文献类型：
--
作者：
Jang, Eun Sun;Jeong, Sook-Hyang;Kim, Hyun Young
背景与目的：咖啡摄入量与肝硬化或肝细胞癌（HCC）的风险呈负相关。然而，在乙肝流行地区，喝咖啡对HCC风险的保护作用尚未确定。在考虑HBV复制状态的情况下，探讨终生咖啡饮用量与HCC发生风险的关系。方法：对1364名患者进行医院病例对照研究。采用标准化问卷对258例HCC患者、480例健康体检者（对照1，HCE）和626例非HCC慢性肝病患者（对照2，CLD）进行吸烟、饮酒和咖啡饮用调查。检测HBV感染患者的HBV e抗原（HBeAg）状态和血清HBV DNA水平。结果：在调整了年龄、性别、肥胖、糖尿病、肝炎病毒（HCE除外）和终生饮酒/吸烟等因素后，在分别使用健康组和危险对照组（HCE组，OR 0.56, 95% CI 0.33-0.95； CLD组，OR 0.55, 95% CI 0.36-0.85）的每个分析中，终生高咖啡饮用量（20000杯）是预防HCC的独立保护因素。然而，在调整HBeAg状态、血清HBV DNA水平和抗病毒治疗后，高咖啡摄入量并未影响HBV患者的HCC风险（OR 0.64, 95% CI 0.36-1.14）。结论：一生中大量饮用咖啡与HCC的发生负相关。然而，在慢性乙型肝炎患者中，由于病毒复制的主导作用，咖啡暴露与HCC组的差异被减小了。
Background & Aims: Coffee consumption is inversely related to the risk of cirrhosis or hepatocellular carcinoma (HCC). However, the protective effect of coffee drinking against the risk of HCC was not established in HBV-prevalent region. To elucidate the relationship between lifetime coffee consumption and the risk of HCC development under the consideration of replication status of HBV. Methods: A hospital-based case-control study was performed in 1364 subjects. A total of 258 HCC patients, 480 health-check examinees (control 1, HCE) and 626 patients with chronic liver disease other than HCC (control 2, CLD) were interviewed on smoking, alcohol and coffee drinking using a standardized questionnaire. HBV e-antigen (HBeAg) status and serum HBV DNA levels were measured in patients infected with HBV. Results: After adjustment for age, gender, obesity, DM, presence of hepatitis virus (except for HCE) and lifetime alcohol drinking/smoking, a high lifetime coffee consumption (20000 cups) was an independent protective factor against HCC, in each analyses using healthy and risky control groups respectively (HCE group, OR 0.56, 95% CI 0.33-0.95; CLD group, OR 0.55, 95% CI 0.36-0.85). However, the high coffee consumption did not affect the HCC risk in patients with HBV (OR 0.64, 95% CI 0.36-1.14) after adjustment for HBeAg status, serum HBV DNA level and antiviral therapy. Conclusions: A high lifetime coffee consumption was negatively associated with a HCC development. However, this difference of coffee exposure with the HCC group was reduced in chronic hepatitis B patients by the dominant role of viral replication.