Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging
Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging
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DOI：
10.1093/gerona/glac097
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xingchun Gou
中科院分区：
文献类型：
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作者：
Xiaojuan Han;Qing Lei;Jiamei Xie;Huanhuan Liu;Haoran Sun;Li Jing;Xiaohua Zhang;Tianying Zhang;Xingchun Gou
Senescent cells express and secrete a variety of extracellular modulators that include cytokines, chemokines, proteases, growth factors and some enzymes associated with ECM remodeling, defined as the senescence-associated secretory phenotype (SASP). SASP reinforces senescent cell cycle arrest, stimulates and recruits immune cells for immune-mediated clearance of potentially tumorigenic cells, limits or induces fibrosis and promotes wound healing and tissue regeneration. On the other hand, SASP mediates chronic inflammation leading to destruction of tissue structure and function and stimulating the growth and survival of tumour cells. SASP is highly heterogeneous and the role of SASP depends on the context. The regulation of SASP occurs at multiple levels including chromatin remodelling, transcription, mRNA translation, intracellular trafficking and secretion. Several SASP modulators have already been identified setting the stage for future research on their clinical applications. In this review, we summarize in detail the potential signalling pathways that trigger and regulate SASP production during ageing and senescence.
