Female versus male migraine: an event-related potential study of visual neurocognitive processing
Female versus male migraine: an event-related potential study of visual neurocognitive processing
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DOI：
10.1186/s10194-019-0995-y
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发表时间：
2019-04-23
影响因子：
7.4
通讯作者：
Liu, Xueping
中科院分区：
文献类型：
--
作者：
Guo, Yunliang;Xu, Song;Liu, Xueping
背景一些研究表明偏头痛患者存在认知缺陷，并且在偏头痛中也观察到性别差异，例如女性的患病率较高。然而，人们对认知过程中与性别有关的差异知之甚少。在这项研究中，我们的目的是探讨性别对神经认知加工在migraineurs.MethodsAltogether，46名偏头痛患者无先兆（23名女性，平均年龄32.848岁）在发作间期和46名年龄匹配的健康对照（23名女性，平均年龄32.652岁）被招募。参与者的情绪特征进行了评估，并通过事件相关电位检查使用三刺激视觉oddball paradig.ResultsWe发现，偏头痛患者患有情绪和视觉认知处理异常与健康对照组相比，包括更高水平的焦虑和减少P3振幅的注意处理进行了分析。这些参数在偏头痛患者中受到性别的调节，但在健康参与者中没有。我们的研究结果表明，女性患者似乎更焦虑，有更严重的损害，在注意处理的视觉刺激比男性同行。偏头痛的性别相关的差异，进一步验证使用事件相关电位差waveforms.ConclusionsThese结果表明，偏头痛可能有额外的影响，女性和导致更多的功能障碍，在他们的发作间期神经认知处理。我们的研究结果提供了偏头痛患者存在性别效应的证据，在设计实验和探索治疗方法时应考虑这一点。偏头痛患者的性别差异和潜在机制值得进一步研究。
BackgroundSeveral studies have suggested cognitive deficits in migraineurs, and sex differences have also been observed in migraine, such as a higher prevalence in females. Nevertheless, little is known about gender-related differences in cognitive processing. In this study, we aimed to investigate the effect of gender on neurocognitive processing in migraineurs.MethodsAltogether, 46 migraine patients without aura (23 females; mean age 32.848years) during the interictal period and 46 age-matched healthy controls (23 females; mean age 32.652years) were recruited. The emotional characteristics of participants were evaluated, and attentive processing was analyzed via event-related potential examinations using a three-stimulus visual oddball paradigm.ResultsWe found that migraineurs suffered from emotional and visual cognitive processing abnormalities compared with healthy controls, including higher levels of anxiety and reduced P3 amplitude. These parameters were modulated by gender in migraine patients, but not in healthy participants. Our findings indicated that female patients seemed to be more anxious and have more severe impairment in attentive processing of visual stimuli than their male counterparts. The gender-related differences in migraineurs were further validated using event-related potential difference waveforms.ConclusionsThese results suggested that migraine might have an additional influence on females and lead to more dysfunction in their interictal neurocognitive processing. Our findings provide evidence that a gender effect exists in migraineurs, which should be considered when designing experiments and exploring treatment approaches. The gender-related differences and underlying mechanisms deserve further investigation for patients with migraine.