SMOKING INDUCES INSULIN RESISTANCE - A POTENTIAL LINK WITH THE INSULIN RESISTANCE SYNDROME
SMOKING INDUCES INSULIN RESISTANCE - A POTENTIAL LINK WITH THE INSULIN RESISTANCE SYNDROME
复制标题
DOI：
10.1111/j.1365-2796.1993.tb00680.x
复制
发表时间：
1993-04-01
影响因子：
11.1
通讯作者：
SMITH, U
中科院分区：
文献类型：
--
作者：
ATTVALL, S;FOWELIN, J;SMITH, U
目标.在一组健康的习惯性吸烟者中研究了吸烟和吸鼻烟对胰岛素敏感性的急性影响。设计将正常血钳夹技术与快速作用胰岛素（Actrapid（R））的推注（0.1 U kg-1）的皮下注射相结合。随机化受试者每小时吸一支烟，持续6小时。每小时吸一袋鼻烟，持续6小时，或在钳夹前和钳夹期间48小时内不吸尼古丁。受试者。七个健康的吸烟者。4名女性和3名男性，体重正常（BMI，平均值± SEM，21 ± 0.7 kg m-2，范围为18.6- 23.9），年龄31 ± 2岁（范围为24-35岁）。研究对象为每天至少吸20支烟至少5年的吸烟者。他们是通过报纸上的广告招募的。稳态血浆尼古丁水平在吸烟和吸鼻烟期间相似。在所有三次钳夹期间，胰岛素和葡萄糖水平也相似。Smoking.而吸鼻烟则不受影响，主要是由于外周葡萄糖摄取降低所致。在6小时的研究中，吸烟组的平均生长激素水平增加了一倍以上（P < 0.01），而其他反调节激素水平没有显着差异。吸烟（也包括习惯性吸烟者）会严重损害胰岛素的作用，导致胰岛素抵抗。因此，吸烟可能对与心血管疾病风险相关的胰岛素抵抗综合征的发展具有重要意义。
Objectives. The acute effect of smoking and snuffing on insulin sensitivity was studied in a group of healthy habitual smokers.Design The euglycaemic clamp technique was combined with the subcutaneous injection of a bolus (0.1 U kg-1) of fast-acting insulin (Actrapid(R)). Randomized subjects smoked either one cigarette per hour for 6 h. took one bag-packed snuff per hour for 6 h or refrained from nicotine for 48 h before as well as during the clamp.Subjects. Seven healthy smokers. four females and three males, of normal weight (BMI, mean +/- SEM, 21 +/- 0.7 kg m-2 with a range of 18.6-2 3.9), aged 31 +/- 2 years (range 24-35 years). who had consumed at least 20 cigarettes per day for at least 5 years were studied. They were recruited through an advertisement in a newspaper.Results. The steady-state plasma nicotine levels were similar during smoking and snuffing. The insulin and glucose levels were also similar during all three clamps. Smoking. but not snuffing, impaired insulin action (P < 0.05) mainly due to a lower peripheral glucose uptake. The mean growth hormone levels during the 6-h study were more than doubled during smoking (P < 0.01) while no significant differences were seen in the other counter-regulatory hormones.Conclusion. Smoking (also in habitual smokers) acutely impairs insulin action and leads to insulin resistance. Thus, smoking can be of importance for the development of the insulin resistance syndrome associated with risk for cardiovascular disease.