Pediatric Inflammatory Multisystem Syndrome Temporally Related With SARS-CoV-2: Immunological Similarities With Acute Rheumatic Fever and Toxic Shock Syndrome.
Pediatric Inflammatory Multisystem Syndrome Temporally Related With SARS-CoV-2: Immunological Similarities With Acute Rheumatic Fever and Toxic Shock Syndrome.
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DOI：
10.3389/fped.2020.00574
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发表时间：
2020
影响因子：
2.6
通讯作者：
Valentini P
中科院分区：
文献类型：
--
作者：
Buonsenso D;Riitano F;Valentini P
几项研究表明，儿童COVID-19是一种相对轻微的疾病。然而，最近出现了一种更严重的疾病，其特征是全身性炎症，并有暴露于SARS-CoV-2的临床或微生物证据。这种综合征现在被称为“与COVID-19暂时相关的儿科炎症多系统综合征”（PIMS-TS）或儿童多系统炎症综合征（MIS-C），目前被认为是一种罕见的COVID-19后并发症，在少数情况下可导致死亡。PIMS-TS的体征和症状在很大程度上与川崎病（KD）和中毒性休克综合征（TSS）重叠，其特征是发烧、全身炎症、腹痛和心脏受累。在本研究中，我们描述了PIMS-TS，急性风湿热和TSS的临床和免疫学特征，旨在为指导未来的临床和基础研究提供假设。
Several studies demonstrated that COVID-19 in children is a relatively mild disease. However, recently a more serious condition characterized by systemic inflammation with clinical or microbiological evidence of exposure to SARS-CoV-2 has been described. This syndrome is now known as either “Pediatric Inflammatory Multisystem Syndrome temporally related with COVID-19” (PIMS-TS), or Multisystem Inflammatory Syndrome in Children (MIS-C) and is currently considered a rare post-COVID-19 complication which, in a minority of cases, can lead to death. The signs and symptoms of PIMS-TS are largely overlapping with the for Kawasaki disease (KD) and toxic shock syndrome (TSS) and are characterized, by fever, systemic inflammation, abdominal pain and cardiac involvement. In this study, we describe clinical and immunological characteristics shared by PIMS-TS, acute rheumatic fever and TSS, in order to provide hypotheses to direct future clinical and basic research studies.
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