Depressive Symptoms and Metabolic Syndrome in Preventive Healthcare: The Cooper Center Longitudinal Study
Depressive Symptoms and Metabolic Syndrome in Preventive Healthcare: The Cooper Center Longitudinal Study
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DOI：
10.1089/met.2010.0017
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发表时间：
2010-10-01
影响因子：
2.1
通讯作者：
Trivedi, Madhukar H.
中科院分区：
文献类型：
--
作者：
East, Cara;Willis, Benjamin L.;Trivedi, Madhukar H.
背景：众所周知，抑郁、代谢综合征和心肺健康（CRF）降低会增加患糖尿病和心血管疾病的风险。在一般健康、活跃且能获得医疗保健的人群中，这些因素之间的关联尚不明确。 方法：这是对 2000 年至 2008 年库珀诊所预防性护理检查期间收集的 5,125 名女性和男性数据进行的横断面分析。主要结果指标是通过流行病学研究中心抑郁量表简表 (CES-D-10) 问卷评估的抑郁症状、存在或不存在 结果：与没有表现出抑郁症状的女性和男性相比，表现出抑郁症状的女性和男性的代谢综合征患病率在统计学上更高（女性为 15.4% vs 7.2%，P < 0.0001；男性为 31.6% vs 22.8%，P < 0.0001）。有抑郁症状的个体腰围较高、甘油三酯较高和高密度脂蛋白较低的频率增加。有抑郁症状的女性空腹血糖水平也略高。调整年龄和吸烟状况后，有抑郁症状的女性患代谢综合征的几率是没有抑郁症状的女性患代谢综合征的几率的 2.81 [95% CI, 2.01-3.93] 倍，而有抑郁症状的男性患代谢综合征的几率是没有抑郁症状的男性的 1.69 (95% CI, 1.42-2.00) 倍。当控制 CRF 水平时，抑郁症状的存在与否与代谢综合征的存在有关，但在女性中仍然具有统计学意义。结论：即使在能够获得医疗保健的总体健康人群中，抑郁症状的存在也与代谢综合征的增加相关。
Background: Depression, metabolic syndrome, and reduced cardiorespiratory fitness (CRF) are known to increase the risk of developing diabetes and cardiovascular disease. The association among these factors in a generally healthy, active population with access to health care is not well defined.Methods: This was a cross-sectional analysis of data collected on 5,125 women and men during preventive care examinations at the Cooper Clinic from 2000 to 2008. The main outcome measures were depressive symptoms as assessed by the Centers for Epidemiologic Studies Depression Scale short form (CES-D-10) questionnaire, presence or absence of metabolic syndrome, and CRF as measured by a maximal exercise treadmill test.Results: Women and men who exhibited depressive symptoms had a statistically higher prevalence of metabolic syndrome compared to those who did not (for women, 15.4% versus 7.2%, P < 0.0001; for men, 31.6% versus 22.8%, P < 0.0001). Individuals with depressive symptoms had an increased frequency of higher waist circumference, higher triglycerides, and lower high-density lipoprotein. Women with depressive symptoms also had marginally higher fasting blood glucose levels. After adjusting for age and smoking status, the odds of metabolic syndrome in women with depressive symptoms was 2.81 [95% confidence interval (CI), 2.01-3.93] times the odds of metabolic syndrome in those without depressive symptoms, and in men with depressive symptoms, the odds were 1.69 (95% CI, 1.42-2.00) times the odds of metabolic syndrome in men without. When controlled for CRF level, the presence or absence of depressive symptoms on the presence of metabolic syndrome is attenuated but remains statistically significant in women.Conclusion: Even in a generally healthy population with access to health care, the presence of depressive symptoms was associated with increased metabolic syndrome.