Adhesion molecules in implantation.
Adhesion molecules in implantation.
复制标题
DOI：
10.1530/ror.0.0020084
复制
发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Aplin, J D
中科院分区：
文献类型：
--
作者：
Aplin, J D
着床时，滋养外胚层附着在子宫顶端腔上皮细胞表面。在人类和小鼠中的分子解剖学研究以及来自实验模型的数据已经确定了可能参与该过程的几种粘附分子：α v家族的整合素、营养素、CD 44、cad-11、H I型和刘易斯y寡糖以及硫酸乙酰肝素。子宫内膜细胞表面粘蛋白MUC 1可能在空间抑制粘附和选择性聚糖展示中发挥作用。附着后，间质性滋养层侵入发生，需要与母体细胞外基质以及基质和血管细胞群体的新的粘附相互作用。人的锚定位点含有细胞滋养层柱，其中自我附着逐渐让位于与细胞外基质的粘附，然后是间质迁移。β 1整合素在着床和胎盘形成的后期阶段是重要的。
At implantation, trophectoderm attaches to the apical uterine luminal epithelial cell surface. Molecular anatomy studies in humans and mice, and data from experimental models have identified several adhesion molecules that could take part in this process: integrins of the alpha v family, trophinin, CD44, cad-11, the H type I and Lewis y oligosaccharides and heparan sulfate. The endometrial cell surface mucin MUC1 may play a role in both steric inhibition of attachment and selective glycan display. After attachment, interstitial trophoblast invasion occurs requiring a new repertoire of adhesive interactions with maternal extracellular matrix as well as stromal and vascular cell populations. Human anchorage sites contain columns of cytotrophoblasts in which self-attachment gives way progressively to adhesion to extracellular matrix and then interstitial migration. The beta 1 integrins are important during these later stages of implantation and placentation.