Vector systems for gene transfer to joints.
Vector systems for gene transfer to joints.
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DOI：
10.1097/00003086-200010001-00004
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发表时间：
2000
影响因子：
4.2
通讯作者：
Thomas J Oligino;Qingping Yao;S. Ghivizzani;Paul D. Robbins
中科院分区：
文献类型：
--
作者：
Thomas J Oligino;Qingping Yao;S. Ghivizzani;Paul D. Robbins
对某些骨科疾病的基因治疗的发展前景已经被这些疾病的分子组成的理解的进步所推动。这些研究已经确定了在某些情况下可能具有治疗或修复作用的分子。转移和适当表达编码这些分子的基因的能力取决于有效基因转移载体的可用性。许多载体系统已被用于在关节中转移和表达基因，并取得了不同程度的成功。目前的审查旨在简要概述不同的基因转移载体系统的基础，可供研究人员在骨科领域使用。
The prospects for the development of gene therapy treatments for certain orthopaedic diseases have been fueled by advances in the understanding of the molecular components of these disorders. These studies have identified molecules that could have therapeutic or reparative effects in certain settings. The ability to transfer and appropriately express the genes encoding these molecules is dependent on the availability of effective gene transfer vectors. Numerous vector systems have been used to transfer and express genes in joints with varied levels of success. The current review is designed to briefly outline the basics of the different gene transfer vector systems available for use by researchers in the orthopaedic fields.