Monoterpene indole alkaloids from the stem bark of Mitragyna diversifolia and their acetylcholine esterase inhibitory effects
Monoterpene indole alkaloids from the stem bark of Mitragyna diversifolia and their acetylcholine esterase inhibitory effects
复制标题
帽柱树皮中单萜吲哚生物碱及其乙酰胆碱酯酶抑制作用
DOI：
10.1016/j.phytochem.2013.10.002
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发表时间：
2013-12-01
期刊：
影响因子：
3.8
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
--
作者：
Cao, Xing-Fen;Wang, Jun-Song;Kong, Ling-Yi
从异叶绣线菊（Mitragyna diversifolia）中分离得到5个单萜吲哚生物碱，分别为具有独特重排骨架的mitradiversifoline、specionoxeine-N（4）-oxide、7-hydroxyisopaynantheine、3-dehydropaynantheine和3-isopaynantheine-N（4）-oxide，以及10个已知生物碱。所有的菌株进行了评价，其抑制乙酰胆碱酯酶的活动，和四个显示出中等活动，与IC 50值分别为4.1，5.2，10.2，和10.3 μ M。(C)2013爱思唯尔有限公司保留所有权利。
Five monoterpene indole alkaloids, mitradiversifoline, with a unique rearranged skeleton, specionoxeine-N(4)-oxide, 7-hydroxyisopaynantheine, 3-dehydropaynantheine, and 3-isopaynantheine-N(4)-oxide, and 10 known ones, were isolated from Mitragyna diversifolia. All the isolates were evaluated for their inhibition of acetylcholinesterase activities, and four showed moderate activities, with IC50 values of 4.1, 5.2, 10.2, and 10.3 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.