Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin
Screen-printed electrodes modified with carbon nanotubes or graphene for simultaneous determination of melatonin and serotonin
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DOI：
10.1007/s00604-015-1520-x
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发表时间：
2015-05
影响因子：
5.7
通讯作者：
F. Gomez;Aida Martin;M. F. Silva;A. Escarpa
中科院分区：
文献类型：
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作者：
F. Gomez;Aida Martin;M. F. Silva;A. Escarpa
单壁碳纳米管 (SWCNT)、多壁碳纳米管 (MWCNT) 和石墨烯已作为碳同素异形体进行了测试，用于修饰碳丝网印刷电极 (CSPE)，以同时测定褪黑激素 (MT) 和血清素 (5-HT)。研究了两组直径均为 4 毫米的 CSPE：第一组包括商用单壁碳纳米管、多壁碳纳米管和石墨烯，第二组包括单壁碳纳米管、多壁碳纳米管、氧化石墨烯纳米带和滴铸在电极上的还原纳米带。碳纳米材料按以下顺序增强电活性面积：CSPE<MWCNT<SWCNT<石墨烯。这样可以分别在 +50 mV 和 +390 mV（相对于 Ag）的工作电位下同时测定 5-HT 和 MT。碳纳米材料的使用，特别是 CSPE 上氧化石墨烯纳米带的使用，代表了一种出色的一次性工具，即使在小样本量中也可以检测两种目标分子。 MT 和 5-HT 的品质因数包括 (a) MT 和 5-HT 的检测限分别为 1.1 和 0.4 μM； (b) 电极间再现性 RSD ≤ 8%； (c) 120 秒响应时间，(d) 回收率（在加标样品的情况下）范围为 94 至 103%（RSD < 1%）。图解摘要丝网印刷电极上的碳纳米材料：智能电化学，用于快速、同步和可靠地检测幸福分子的血清素和黑暗分子的褪黑素。
Single-walled carbon nanotubes (SWCNT), multi-walled carbon nanotubes (MWCNT) and graphene have been tested as carbon allotropes for the modification of carbon screen-printed electrodes (CSPEs) to simultaneously determine melatonin (MT) and serotonin (5-HT). Two groups of CSPEs, both 4 mm in diameter, were explored: The first includes commercial SWCNT, MWCNT and graphene, the second includes SWCNT, MWCNT, graphene oxide nanoribbons and reduced nanoribbons that were drop casted on the electrodes. The carbon nanomaterials enhanced the electroactive area in the following order: CSPE <MWCNTs <SWCNTs <graphene. This allowed the simultaneous determination of 5-HT and MT at the working potentials of +50 mV and +390 mV (vs. Ag), respectively. The use of carbon nanomaterials, in particular of graphene oxide nanoribbons on CSPEs, represents an excellent and disposable tool for sensing the two target molecules in even small sample volumes. Figures of merit for MT and 5-HT include (a) detection limit of 1.1 and 0.4 μM for MT and 5-HT, respectively; (b) an inter-electrode reproducibility with RSD ≤ 8 %; (c) 120 s response time, and (d) recoveries (in case of spiked samples) ranging from 94 to 103 % (with an RSD < 1 %).Graphical AbstractCarbon nanomaterials on screen-printed electrodes: smart electrochemistry for fast, simultaneous and reliable detection of serotonin the molecule of happiness and melatonin the molecule of darkness.