Effect of cyclooxygenase blockade on blood flow through well-developed coronary collateral vessels.
Effect of cyclooxygenase blockade on blood flow through well-developed coronary collateral vessels.
复制标题
环氧合酶阻断对通过发育良好的冠状侧支血管的血流的影响。
DOI：
10.1161/01.res.70.6.1091
复制
发表时间：
1992
影响因子：
20.1
通讯作者：
Bache,RJ
中科院分区：
文献类型：
--
作者：
Altman,J;Dulas,D;Bache,RJ
冠状动脉闭塞后形成的侧支血管表现为血管周围炎症、内膜下增生和内皮增生。本研究旨在检验这些异常与血管扩张剂异丙肾上腺素产生增加相关的假设。8只狗在冠状动脉前降支闭塞后4-6个月进行了研究，以刺激侧支血管生长。在研究时，在闭塞部位对冠状动脉前降支插管，以测量逆行血流作为动脉间侧支血流的指标。在逆行血流收集过程中注射放射性微球，可以确定侧支依赖区的持续组织血流作为壁内微血管侧支血流的指标。在静脉注射5 mg/kg吲哚美辛之前和之后20分钟测量逆行和组织流量，该剂量对500 μ g花生四烯酸的冠状动脉内推注产生95 +/- 3%的冠状动脉血管舒张抑制。心率和平均主动脉压没有显着改变吲哚美辛，血流正常灌注心肌区域没有改变吲哚美辛的管理。然而，吲哚美辛导致逆行血流减少40 +/- 7%（p <0.01），依赖性心肌的微血管侧支血流减少20 +/- 10%（p <0.05）。这些数据表明，与正常的冠状动脉循环不同，发育良好的冠状动脉侧支血管受到血管扩张剂三尖杉酯碱的紧张性影响。
Collateral vessels that develop after coronary artery occlusion demonstrate perivascular inflammation, subintimal hyperplasia, and endothelial proliferation. This study was performed to test the hypothesis that these abnormalities are associated with evidence for increased production of vasodilator prostaglandins. Eight dogs were studied 4-6 months after occlusion of the anterior descending coronary artery had been performed to stimulate collateral vessel growth. At the time of study, the anterior descending coronary artery was cannulated at the site of occlusion to allow measurement of retrograde blood flow as an index of interarterial collateral flow. Injection of radioactive microspheres during the retrograde flow collection allowed determination of continuing tissue flow in the collateral-dependent zone as an index of intramural microvascular collateral flow. Retrograde and tissue flows were measured before and 20 minutes after 5 mg/kg i.v. indomethacin, a dose that caused 95 +/- 3% inhibition of the coronary vasodilation in response to a 500 micrograms intracoronary bolus of arachidonic acid. Heart rate and mean aortic pressure were not significantly altered by indomethacin, and blood flow to the normally perfused myocardial region was not changed by administration of indomethacin. However, indomethacin caused a 40 +/- 7% decrease in retrograde flow (p less than 0.01), and microvascular collateral flow to the dependent myocardium decreased by 20 +/- 10% (p less than 0.05). These data indicate that, unlike the normal coronary circulation, well-developed coronary collateral vessels are under the tonic influence of vasodilator prostaglandins.