An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions
An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions
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DOI：
10.1016/j.tetlet.2008.12.053
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发表时间：
2009-03-04
影响因子：
1.8
通讯作者：
Paul, Vincent
中科院分区：
文献类型：
--
作者：
Borikar, Sanjay P.;Daniel, Thomas;Paul, Vincent
1-丁基-3-甲基吡啶鎓三溴化物，[BMPy]Br-3 被证明是一种高效的区域选择性试剂/溶剂，用于各种苯胺和酚的核溴化。描述了室温离子液体[BMPy]Br-3 (2)的合成和表征。溴化是在没有有机溶剂的情况下进行的，在大多数情况下，唯一需要的萃取溶剂是水。废的1-丁基-3-甲基溴化吡啶鎓(1)很容易回收。 (C) 2008 Elsevier Ltd. 保留所有权利。
1-Butyl-3-methylpyridinium tribromide, [BMPy]Br-3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br-3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled. (C) 2008 Elsevier Ltd. All rights reserved.