Clinical utility of long latency 'cognitive' event-related potentials (P3): the pros.
Clinical utility of long latency 'cognitive' event-related potentials (P3): the pros.
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长潜伏期“认知”事件相关电位 (P3) 的临床实用性：优点。
DOI：
10.1016/0013-4694(90)90051-k
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
D. Goodin
中科院分区：
文献类型：
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作者：
D. Goodin
一些电生理学研究，如长潜伏期“认知”事件相关电位(ERPs)的临床应用仍存在争议。一些作者对这个问题进行了研究，但没有形成共识。大多数关于事件相关电位的临床研究都是关于P3或P300成分的，因此我的评论将仅限于对该成分及其临床作用的讨论。P3是在受试者正在注意的罕见刺激后大约300毫秒出现的正电波。从实验上看，它与预期、任务难度和记忆力等变量有关。由于这种与认知功能的明显关系，它被用于评估痴呆症患者，以区分可能出现在抑郁症或其他精神疾病中的真正的痴呆症和假性痴呆症。大多数作者同意，如果P3反应允许做出这种区分，这项测试将具有临床价值。因此，存在的争议主要与作出这一区分的测试的可靠性有关。对于P3的临床效用有许多不同意见的原因，包括对什么是临床效用的混淆。一个有启发性的例子是比较两个
The clinical utility of some electrophysiologic studies such as long latency'cognitive'event-related potentials (ERPs) remains controversial. A number of authors have studied this question but no consensus of opinion had emerged. Most clinical studies on the ERP have been on the P3 or P300 component and my remarks will therefore be confined to a discussion of this component and its clinical role. P3 is an electropositive wave that occurs approximately 300 msec after an infrequently occurring stimulus to which the subject is attending. It has been linked experimentally to such variables as expectancy, task difficulty and memory. Because of this apparent relationship to'cognitive'functions, it has been used to evaluate demented patients in order to distinguish'true'dementia from the pseudodementia that can occur in depression or other psychiatric disorders. Most authors agree that if the P3 response permitted this distinction to be made, the test would be of clinical value. Thus, the controversy that exists relates principally to the reliability of the test in making this distinction. There are many reasons for the differences of opinion regarding the clinical utility of P3, including confusion about what constitutes clinical utility. An instructive example is to compare two
听神经瘤患者的正常脑干听觉诱发电位与异常潜伏期强度研究。
影响因子：
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作者：
Legatt,AD;Pedley,TA;Emerson,RG;Stein,BM;Abramson,M
通讯作者：
Abramson,M
衰老、阿尔茨海默型痴呆和抑郁症中听觉事件相关电位成分对不频繁刺激的潜伏期变异性。
DOI：
10.1016/0168-5597(88)90049-4
发表时间：
1988
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
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作者：
Patterson,JV;Michalewski,HJ;Starr,A
通讯作者：
Starr,A