Severe cardiovascular depression with remifentanil
Severe cardiovascular depression with remifentanil
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DOI：
10.1097/00000539-200007000-00011
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发表时间：
2000-07-01
影响因子：
5.7
通讯作者：
Mirakhur, RK
中科院分区：
文献类型：
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作者：
Elliott, P;O'Hare, R;Mirakhur, RK
我们比较了瑞芬太尼1、3和5min(1、0.33和0.2mug/kg)团注给药对血流动力学的影响。Kg(-1)。小剂量异丙酚麻醉下行冠状动脉旁路移植术患者的麻醉时间分别为min(-1)。这项研究在只有8名患者入选后终止(其中3名患者接受了1.0微克的瑞芬太尼治疗。Kg(-1)。Min(-1)，两个0.33微克。Kg(-1)。Min(-1)，三个0.2微克。Kg(-1)。分钟(-1))，因为严重的血流动力学不稳定，这在4名患者中尤其明显，包括1名患者严重心动过缓和3名其他患者严重低血压并伴有全身血管阻力下降。一名患者表现出心肌缺血的证据。所有患者对治疗干预均有反应。结果表明，瑞芬太尼只能缓慢输注给药。
We compared the hemodynamic effects of a bolus administration of 1 mu g/kg remifentanil for 1, 3, and 5 min (1, 0.33, and 0.2 mu g . kg(-1) . min(-1), respectively) in patients scheduled for coronary artery bypass grafting anesthetized with small-dose propofol. The study was terminated after only eight patients had been enrolled (three received remifentanil at a rate of 1.0 mu g . kg(-1) . min(-1), two at 0.33 mu g . kg(-1) . min(-1), and three at 0.2 mu g . kg(-1) . min(-1)) because of severe hemodynamic instability, which was particularly marked in four patients and consisted of severe bradycardia in one patient and severe hypotension with a reduction in systemic vascular resistance in three others. One patient showed evidence of myocardial ischemia. All patients responded to therapeutic interventions. The results show that remifentanil should be given only by slow infusion to such patients.