Self-Focused Ruminations and Memory Deficits in Obsessive-Compulsive Disorder
Self-Focused Ruminations and Memory Deficits in Obsessive-Compulsive Disorder
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DOI：
10.1007/s10608-007-9162-x
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发表时间：
2009-04-01
影响因子：
2.8
通讯作者：
Rief, Winfried
中科院分区：
文献类型：
--
作者：
Exner, Cornelia;Martin, Vera;Rief, Winfried
之前的研究表明，强迫症（OCD）患者存在记忆缺陷，但对于记忆的哪些方面受到影响以及记忆缺陷与强迫症症状之间的关系，研究结果并不一致。目前的研究评估了19名强迫症患者和19名对照者的工作记忆、情景记忆和语义记忆。使用临床评定量表（Yale-Brown Obsessive-Compulsive scale, Y-BOCS）和自我报告量表（Padua Inventory-Revised, PI-R）评估强迫症症状的严重程度。与对照组相比，强迫症受试者的情景记忆和语义记忆表现明显下降，而工作记忆则得到保留。在控制抑郁情绪和总体强迫症症状严重程度的情况下，强迫症和健康对照组的情景记忆表现与Padua维度反刍和检查均显著相关。线性回归结果显示，反刍与情景记忆表现的关系最为密切。结果表明，自我集中注意可能对费力的编码过程产生影响。
Previous research has shown memory deficits in obsessive-compulsive disorder (OCD) but has been inconsistent as to which aspects of memory are affected and how deficits are linked to OCD symptoms. The current study assessed working, episodic and semantic memory in 19 subjects with OCD and 19 matched controls. The severity of OCD symptoms was assessed using a clinician-rated scale (Yale-Brown Obsessive-Compulsive Scale, Y-BOCS) and a self-report measure (Padua Inventory-Revised, PI-R). Episodic and semantic memory performance was significantly reduced in OCD subjects relative to controls while working memory was preserved. Episodic memory performance in both OCD and healthy control subjects was significantly related to the Padua dimensions Rumination and Checking even if the influence of depressive mood and total OC symptom severity was controlled for. Linear regression revealed that Rumination was most closely related to episodic memory performance in both OCD and healthy control subjects above Checking. Results point to the possible impact of self-focused attention on effortful encoding processes.