ALTERATIONS OF THE CAPPING PHENOMENON ON LYMPHOCYTES FROM AGED AND DOWNS-SYNDROME SUBJECTS
ALTERATIONS OF THE CAPPING PHENOMENON ON LYMPHOCYTES FROM AGED AND DOWNS-SYNDROME SUBJECTS
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DOI：
10.1159/000212622
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发表时间：
1984-01-01
期刊：
影响因子：
3.5
通讯作者：
FRANCESCHI, C
中科院分区：
文献类型：
--
作者：
CHIRICOLO, M;MINELLI, L;FRANCESCHI, C
13例老年受试者外周血淋巴细胞中加入FITC[异硫氰酸荧光素]-Con A后，细胞1极Con A受体随时间的重新分布（所谓的capping）。1岁)，以及16名患有早衰综合征（如唐氏综合征）的非住院患者(平均：17.1 +-。（2岁），并与一组15名正常青少年(平均：23 .+-。2岁)。在封顶细胞的百分比中，观察到相反的变化，即在老年受试者中减少，而在唐氏综合征患者中增加。淋巴细胞膜流动性紊乱似乎存在于两组，即使潜在的生化缺陷可能不同。在老年或唐氏综合症患者中也出现了类似的动力学变化。两组的盖顶细胞百分比都没有随着时间的推移而显著增加，这表明它们缺乏一个较晚开始盖顶的淋巴细胞亚群。
The redistribution with time of concanavalin A (Con A) receptors at 1 pole of the cell after addition of FITC[fluorescein isothiocyanate]-Con A (so-called capping) in the peripheral blood lymphocytes from 13 aged subjects (mean: 84 .+-. 1 yr old), and of 16 noninstitutionalized patients affected by a syndrome of precocious aging, such as Down''s syndrome (mean: 17 .+-. 2 yr old), was studied and compared with a group of 15 normal young people (mean: 23 .+-. 2 yr old). An opposite alteration in the percentage of capped cells, i.e., a decrease in aged subjects and an increase in Down''s syndrome patients, was observed. A derangement of lymphocyte membrane fluidity appears to be present in both groups even if the underlying biochemical defect may be different. A similar alteration of the kinetics of the phenomenon was present either in aged or in Down''s syndrome subjects. Both groups did not show any significant increase with time of the percentage of capped cells, suggesting that they were lacking a lymphocyte subpopulation(s) which start capping later.