Baseline STD prevalence in a community intervention trial of the female condom in Kenya
Baseline STD prevalence in a community intervention trial of the female condom in Kenya
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DOI：
10.1136/sti.76.6.454
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发表时间：
2000-12-01
影响因子：
3.6
通讯作者：
Welsh, M
中科院分区：
文献类型：
--
作者：
Feldblum, PJ;Kuyoh, M;Welsh, M
目标：我们目前的基线性传播疾病（STD）的患病率从一个正在进行的干预试验在肯尼亚agricultural sites.Methods：获得合作的管理后，我们确定了6对匹配的茶叶，咖啡，花卉种植园，并在每个网站招收约160名妇女。六个干预点接受了信息方案，并分发了女用和男用避孕套，而六个对照点只收到男用避孕套和类似的信息。在门诊访视时，我们通过连接酶链反应对尿液标本进行宫颈淋病（GC）和沙眼衣原体（CT）检测，并通过培养检测阴道毛滴虫（TV）。本研究有80%的把握度在随访期间检测到10%的患病率差异，假设合并的STD患病率为20%，失访率为25%，群内相关系数（ICC）为0.03。平均年龄为33岁，大多数已婚，超过一半的人目前使用计划生育，78%的人从未使用过男性避孕套，9%的人在研究前3个月内报告有一个性伴侣。GC、CT和TV的患病率分别为2.6%、3.2%和20.4%（总体为23.9%），在干预和对照部位相似。性病患病率的ICC为0.0011。基线STD与未婚状态、不使用计划生育、饮酒和最近有一个以上性伴侣有关，但最高比值比为1.5。结论：基线结果证实了肯尼亚农村地区滴虫病和细菌性STD的高患病率。那里迫切需要改进性病管理。我们正在进行的女用避孕套干预试验按设计是可行的。
Objective: We present baseline sexually transmitted disease (STD) prevalence rates from an ongoing intervention trial at Kenyan agricultural sites.Methods: After gaining the cooperation of management, we identified six matched pairs of tea, coffee, and flower plantations and enrolled approximately 160 women at each site. Six intervention sites received an information programme and distributed female and male condoms, while six control sites received male condoms only and similar information about them. At clinic visits, we tested participants for cervical gonorrhoea (GC) and Chlamydia trachomatis (CT) by ligase chain reaction on urine specimens, and Trichomonas vaginalis (TV) by culture. The study has 80% power to detect a 10% prevalence difference during follow up, assuming a combined STD prevalence of 20%, 25% loss to follow up and intracluster correlation coefficient (ICC) of 0.03.Results: Participants at intervention and control sites (total 1929) were similar at baseline. Mean age was 33 years, the majority were married, more than half currently used family planning, 78% had never used male condoms, and 9% reported more than one sexual partner in the 3 months before the study. Prevalences of GC, CT, and TV were 2.6%, 3.2%, and 20.4% respectively (23.9% overall), and were similar at intervention and control sites. The ICC for STD prevalence was 0.0011. Baseline STD was associated with unmarried status, non-use of family planning, alcohol use, and more than one recent sexual partner, but the highest odds ratio was 1.5.Conclusions: Baseline results confirm a high prevalence of trichomoniasis and bacterial STD at these Kenyan rural sites. Improved STD management is urgently needed there. Our ongoing female condom intervention trial is feasible as designed.