Regional cerebral glutamate concentrations and chronic tobacco consumption
Regional cerebral glutamate concentrations and chronic tobacco consumption
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DOI：
10.1055/s-2007-970144
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发表时间：
2007-03-01
影响因子：
4.3
通讯作者：
Schubert, F.
中科院分区：
文献类型：
--
作者：
Gallinat, J.;Schubert, F.
越来越多的证据表明谷氨酸在大脑奖励系统和尼古丁成瘾中起着至关重要的作用。由于相关模型涉及额叶和海马的谷氨酸能投射，我们的目标是研究不同吸烟行为的健康受试者的大脑谷氨酸浓度。方法：采用质子磁共振波谱法测定13例慢性吸烟者、9例戒烟者和16例不吸烟者左海马和前扣带皮层（ACC） 3特斯拉的谷氨酸水平。结果：两组间谷氨酸浓度无显著性差异（F=1.151, df=2， P=0.340）。未观察到谷氨酸浓度与吸烟年龄、每日卷烟消费或终生暴露于烟草烟雾（包年）之间的显著相关性。结论：我们的研究结果不支持扣带或海马谷氨酸浓度在慢性烟草消费中的关键作用。然而，除了由于样本量有限而可能被忽视的组差异之外，这些结果不能排除吸烟者的谷氨酸神经传递功能障碍或其他大脑区域的谷氨酸功能障碍。
Introduction: Increasing evidence indicates a crucial role of glutamate in the brain reward system and nicotine addiction. Because the pertinent models involve frontal and hippocampal glutamatergic projections, our goal was to investigate cerebral glutamate concentrations in healthy subjects with different smoking behavior.Methods: Glutamate was measured with proton magnetic resonance spectroscopy at 3 tesla in the left hippocampus and anterior cingulate cortex (ACC) in 13 chronic tobacco smokers, 9 former smokers, and 16 never-smokers using a dedicated quantification method.Results: Glutamate concentrations did not differ between groups in either voxel (F=1.151, df=2, P=0.340). No significant correlations between glutamate concentrations and age of smoking onset, daily cigarette consumption, or lifetime exposure to tobacco smoke (pack-years) were observed.Conclusion: Our findings do not support a crucial role of cingulate or hippocampal glutamate concentration in chronic tobacco consumption. Besides group differences potentially gone unnoticed due to the limited sample size, however, these results cannot rule out dysfunctional glutamatergic neurotransmission or glutamate dysfunctions in other brain regions of smokers.