Hepatoprotective effect of total flavonoids fromGlycyrrhiza uralensisFisch in liver injury mice
Hepatoprotective effect of total flavonoids fromGlycyrrhiza uralensisFisch in liver injury mice
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DOI：
10.1080/14786419.2020.1824223
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发表时间：
2020-09-26
影响因子：
2.2
通讯作者：
Ni, Jing-man
中科院分区：
文献类型：
--
作者：
Gou, San-hu;He, Miao;Ni, Jing-man
为研究甘草总黄酮的保肝作用，从甘草中分离出甘草总黄酮（LTF）的主要成分，其总含量超过60%。采用高脂乳剂、白酒和四氯化碳三种肝损伤模型，观察LTF对小鼠肝损伤的保护作用。LTF可降低肝损伤小鼠血清ALT、AST、ALP水平及肝组织MDA、TG、胆固醇、羟脯氨酸含量。同时，肝SOD和谷胱甘肽增加LTF。这些结果表明，LTF可以通过减轻炎症、提高抗氧化酶活性和降低肝组织氧化应激来修复肝组织并减轻肝损伤，可能是一种有价值的天然保肝活性来源。
This work aimed to investigate the hepatoprotective effect of total flavonoids fromGlycyrrhiza uralensis.The main compounds in licorice total flavonoids (LTF) were isolated fromGlycyrrhiza uralensisand their total content in LTF were more than 60%. Hepatoprotective effects of LTF were investigated in three kinds of hepatic injury mice model induced by high-fat emulsion, Chinese liquor and tetrachloromethane. Serum ALT, AST and ALP levels and hepatic MDA, TG, cholesterol, and hydroxyproline of hepatic injury mice were reduced by LTF. Simultaneously, hepatic SOD and glutathione were increased by LTF. These results suggested that LTF can repair liver tissue and reduce hepatic injury via alleviating inflammation, improving antioxidant enzyme activity and reducing oxidative stress in liver tissue and it may be a valuable natural source of hepatoprotective activity.