6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction
6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction
复制标题
6-姜酚改善与年龄相关的肝脂肪变性：与调节脂肪生成、脂肪酸氧化、氧化应激和线粒体功能障碍相关
DOI：
10.1016/j.taap.2018.11.001
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发表时间：
2019-01-01
影响因子：
3.8
通讯作者：
Wang, Jianwei
中科院分区：
文献类型：
--
作者：
Li, Jinxiu;Wang, Shang;Wang, Jianwei
NAFLD的患病率随着年龄的增长而增加。6-姜辣素作为生姜的主要活性成分，能显著改善成年啮齿类动物的脂质代谢异常。然而，很少有研究报道其对年龄相关的NAFLD的影响。本研究旨在探讨6-姜辣素对年龄相关性脂肪肝的作用及其可能的作用靶点。正如预期的那样，6-姜辣素显着正常化的肝脏甘油三酯含量，血浆胰岛素和HOMA-IR指数的老龄大鼠。从机制上讲，6-姜辣素通过激活PPAR α和CPT 1 α以及抑制DGAT-2来增加β-氧化和减少脂肪生成，从而影响脂质代谢。此外，6-姜酚逆转了柠檬酸盐，Cs和ATP的减少，减轻了ROS引起的损伤，并上调了衰老肝脏中的线粒体标记酶NOX，SDH和SIRT 3，表明其能够增强线粒体功能。我们的研究结果表明，6-姜酚通过调节Akt对胰岛素敏感性产生积极影响。总之，6-姜辣素的肝脏抗脂肪变性作用与抑制从头脂肪生成、上调脂肪酸氧化、减少氧化应激和协同增强线粒体功能有关。
The prevalence of NAFLD increases with age. As the main active ingredient of ginger, 6-gingerol significantly improves lipid metabolism abnormalities in adult rodents. However, few studies have reported its effect on age-related NAFLD. This study was to investigate the effects of 6-gingerol on age-related hepatic steatosis and its potential targets. As expected, 6-gingerol dramatically normalized the hepatic triglyceride content, plasma insulin and HOMA-IR index of ageing rats. Mechanistically, 6-gingerol affected lipid metabolism by increasing beta-oxidation and decreasing lipogenesis through activation of PPAR alpha and CPT1 alpha and inhibition of DGAT-2. Furthermore, 6-gingerol reversed the decreases in citrate, Cs and ATP, lessened the damage caused by ROS, and upregulated mitochondrial marker enzymes NOX, SDH, and SIRT3 in the ageing liver, indicating its ability to strengthen mitochondria' function. Our results showed 6-gingerol exerted a positive effect on insulin sensitivity by regulating Akt. In conclusion, the hepatic anti-steatotic effect of 6-gingerol is associated with inhibition of de novo lipogenesis, upregulation of fatty acid oxidation, reduction in oxidative stress and synergistic enhancement of mitochondrial function.