CORTICOSTERONE RHYTHMICITY IN THE RAT - INTERACTIVE EFFECTS OF DIETARY RESTRICTION AND SCHEDULE OF FEEDING
CORTICOSTERONE RHYTHMICITY IN THE RAT - INTERACTIVE EFFECTS OF DIETARY RESTRICTION AND SCHEDULE OF FEEDING
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DOI：
10.1093/jn/111.2.208
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
WEINBERG, J
中科院分区：
文献类型：
--
作者：
GALLO, PV;WEINBERG, J
研究了饲粮组成和限食时间的变化对成年大鼠血浆皮质酮昼夜节律的影响。采用三种限饲计划：开灯后3小时、熄灯前1小时或连续供料。动物与对照组配对（食用24%蛋白质饮食），每天提供对照组食物摄入量/克体重的80%。第4试验组随机饲喂蛋白质含量为2.4%的饲粮。从0800-0400小时，每4小时测量一次血浆皮质激素水平。同时测定食物呈现后20分钟的皮质激素水平。对照组和限制蛋白喂养的动物均表现出典型的昼夜节律，皮质激素在0800 h最低，在2000 h达到峰值。0900 h喂养的动物皮质激素峰值移动了12小时，而自动喂食的动物完全没有昼夜节律。在1700小时提供限制口粮导致与对照组相似的昼夜节律。虽然在对照组和限制蛋白质的动物中，喂食前和喂食后的皮质激素相似，但在所有3个限制食物的动物中，喂食后的皮质激素均被抑制。显然，在营养范式中，摄食计划和昼夜节律之间的关系不容忽视。
Effects of changes in diet composition and schedule of restricted feeding on the circadian rhythm of plasma corticosterone in the adult rat were examined. Three restricted feeding schedules were used: diet presented 3 h after lights-on, 1 h before light-off or continuously by automated feeder. Animals were paired to controls (consuming 24% protein diet ad lib) and provided 80% of control food intake/g body weight per day. A 4th experimental group was offered 2.4% protein diet ad lib. Plasma corticoids were measured every 4 h from 0800-0400 h. Corticoid levels 20 min after food presentation were also determined. Both control and protein-restricted animals displayed a typical circadian rhythm, with corticoids lowest at 0800 h and a peak at 2000 h. Animals fed at 0900 h exhibited a 12 h shift in peak corticoids, while the circadian rhythm was totally abolished in animals fed by automated feeder. Offering the restricted ration at 1700 h resulted in a diurnal rhythm similar to that of controls. While pre and post-feeding corticoids were similar in control and protein-restricted animals, a post-feeding suppression was found in all 3 food-restricted groups. Clearly, the relationship between feeding schedule and diurnal rhythm must not be ignored in nutritional paradigms.