Correlation of electrical and mechanical responses in nervous control of cilia
Correlation of electrical and mechanical responses in nervous control of cilia
复制标题
纤毛神经控制中电反应和机械反应的相关性
作者：
A. Murakami;K. Takahashi
尽管纤毛在大多数动物门中具有许多重要的功能，但我们对其活动控制机制的了解还很有限。利用细胞内微电极对纤毛细胞进行了广泛的电生理学研究，但只对相对较大的原生动物（主要是草草虫）进行了研究，其中纤毛活性已被证明与细胞膜的电特性密切相关。在后生动物中，已报道了一些神经控制纤毛活动的例子4，但主要由于技术上的困难，仅在少数情况下记录了纤毛细胞的膜电位5,6；在任何情况下，通过同时记录电和机械事件来研究纤毛的神经控制。这样的记录对于在细胞水平上理解神经控制机制是必不可少的。
ALTHOUGH cilia have many important functions in the majority of animal phyla, our knowledge about the mechanism by which their activity is controlled has been fragmentary1. Extensive electrophysiological studies of the ciliated cell, with intracellular microelectrodes, have been made only with the relatively large protozoans, principally Paramecium, where the ciliary activity has been shown to be closely associated with the electrical properties of the cell membrane2,3. Among the metazoans, some examples of nervous control of ciliary activity have been reported4, but, mainly because of technical difficulties, intracellular recording of the membrane potential from the ciliated cells has been made in only a few cases5,6; in no case has nervous control of cilia been studied by recording simultaneously the electrical and the mechanical events. Such recording is essential to understanding the mechanism of nervous control at the cellular level.