Positive diversifying selection is a pervasive adaptive force throughout the Drosophila radiation
Positive diversifying selection is a pervasive adaptive force throughout the Drosophila radiation
复制标题
DOI：
10.1016/j.ympev.2017.04.023
复制
发表时间：
2017-07-01
影响因子：
4.1
通讯作者：
Steiner, Florian M.
中科院分区：
文献类型：
--
作者：
Cicconardi, Francesco;Marcatili, Paolo;Steiner, Florian M.
越来越多的非模式生物基因组信息有助于探索生物多样性的进化史。对于果蝇来说尤其如此，果蝇的测序物种数量最近翻了一番。果蝇由于其突出的物种多样性，已成为研究适应辐射的重要系统之一。在这项研究中，我们对25个物种的2000多个单拷贝同源群体进行了正多样化选择的全基因组分析，使用了一种提高检测正多样化选择准确性的新方法。采用这种新方法，我们在整个果蝇属中发现了一致的选择信号，共鉴定出1342个单拷贝同源类群，对应于所有位点的1.9%，具有假定的正向多样化选择信号。具体来说，在导致D. grimshawi的谱系中，发现了与细胞、形态、神经元和感觉发育和功能相关的强烈的正向多样化选择信号。在与衰老和寿命相关的基因上发现了积极多样化选择的循环信号，这表明选择塑造了果蝇的寿命多样性，包括极端长寿。我们的研究是迄今为止最大和最全面的全基因组正多样化选择研究之一，表明正多样化选择促进了整个果蝇辐射进化谱系之间的物种特异性分化。正向多样化选择通过不同途径作用于相同的生物过程，促进了功能多样性和适应性分化。(C) 2017年作者。Elsevier Inc.出版。
The growing genomic information on non-model organisms eases exploring the evolutionary history of biodiversity. This is particularly true for Drosophila flies, in which the number of sequenced species doubled recently. Because of its outstanding diversity of species, Drosophila has become one of the most important systems to study adaptive radiation. In this study, we performed a genome-wide analysis of positive diversifying selection on more than 2000 single-copy orthologous groups in 25 species using a recent method of increased accuracy for detecting positive diversifying selection. Adopting this novel approach enabled us to find a consistent selection signal throughout the genus Drosophila, and a total of 1342 single-copy orthologous groups were identified with a putative signal of positive diversifying selection, corresponding to 1.9% of all loci. Specifically, in lineages leading to D. grimshawi, a strong putative signal of positive diversifying selection was found related to cell, morphological, neuronal, and sensorial development and function. A recurrent signal of positive diversifying selection was found on genes related to aging and lifespan, suggesting that selection had shaped lifespan diversity in Drosophila, including extreme longevity. Our study, one of the largest and most comprehensive ones on genome-wide positive diversifying selection to date, shows that positive diversifying selection has promoted species specific differentiation among evolutionary lineages throughout the Drosophila radiation. Acting on the same biological processes via different routes, positive diversifying selection has promoted diversity of functions and adaptive divergence. (C) 2017 The Authors. Published by Elsevier Inc.