MALABSORPTION AND DEFECTIVE UTILIZATION OF IRON IN 3 SIBLINGS
MALABSORPTION AND DEFECTIVE UTILIZATION OF IRON IN 3 SIBLINGS
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DOI：
10.1016/s0022-3476(81)80831-1
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发表时间：
1981-01-01
影响因子：
5.1
通讯作者：
SHEEHAN, RG
中科院分区：
文献类型：
--
作者：
BUCHANAN, GR;SHEEHAN, RG
三个兄弟姐妹有缺铁性贫血，没有证据表明铁摄入量减少或胃肠道失血。他们未能响应口服铁治疗，口服药用铁吸收不良表现在2名儿童。所有3例患者均对i.m.有部分但不完全的血液学反应。铁葡聚糖治疗。没有证据表明其他明确的原因导致低色素性小细胞性贫血或全身性肠道吸收障碍。这3例患者似乎有一个家族性疾病的特点是受损的铁吸收和利用，类似于在小鼠中观察到的。
Three siblings had Fe deficiency anemia without evidence of reduced Fe intake or gastrointestinal blood loss. They failed to respond to oral Fe therapy, and malabsorption of oral medicinal Fe was demonstrated in 2 of the children. All 3 had a partial but incomplete hematologic response to i.m. Fe dextran treatment. There was no evidence for other well-defined causes of hypochromic microcytic anemia or for a generalized disorder of intestinal absorption. These 3 patients appear to have a familial disorder characterized by impaired Fe absorption and utilization, similar to that observed in the mk/mk mouse.