The recency ratio is associated with reduced CSF glutamate in late-life depression.
The recency ratio is associated with reduced CSF glutamate in late-life depression.
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DOI：
10.1016/j.nlm.2017.03.011
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发表时间：
2017-05
影响因子：
2.7
通讯作者：
Pomara N
中科院分区：
文献类型：
--
作者：
Bruno D;Nierenberg J;Cooper TB;Marmar CR;Zetterberg H;Blennow K;Hashimoto K;Pomara N
谷氨酸是中枢神经系统中的主要兴奋性神经递质，并且被认为参与记忆编码和存储过程。谷氨酸紊乱也被报道在精神疾病中，如精神分裂症和重度抑郁症（MDD），以及阿尔茨海默病中。在本文中，我们着手研究脑脊液（CSF）谷氨酸水平和记忆性能之间的关系，我们认为这是以前没有报道过的。特别是，我们专注于按序列位置细分的召回性能。我们的预测是，近因比（Rr），一种新的认知标志物的智力障碍，将与脑脊液谷氨酸水平。我们研究了一组认知功能完整的老年人的数据，其中28人患有MDD，而19人是对照组。研究结果表明，Rr水平，但没有其他记忆评分，与CSF谷氨酸水平呈负相关，尽管这只在患有晚期MDD的个体中发现。相比之下，谷氨酰胺或GABA与任何记忆性能指标无关。
Glutamate is the principal excitatory neurotransmitter in the central nervous system, and is thought to be involved in the process of memory encoding and storage. Glutamate disturbances have also been reported in psychiatric disorders, such as schizophrenia and major depressive disorder (MDD), and in Alzheimer’s disease. In this paper, we set out to study the relationship between cerebrospinal fluid (CSF) glutamate levels and memory performance, which we believe has not been reported previously. In particular, we focused on recall performance broken down by serial position. Our prediction was that the recency ratio (Rr), a novel cognitive marker of intellectual impairment, would be linked with CSF glutamate levels. We studied data from a group of cognitively intact elderly individuals, 28 of whom had MDD, while 19 were controls. Study results indicated that Rr levels, but no other memory score, were inversely correlated with CSF glutamate levels, although this was found only in individuals with late-life MDD. For comparison, glutamine or GABA were not correlated with any memory performance measure.