Anticoagulant therapy in cerebral vascular disease; current status.
Anticoagulant therapy in cerebral vascular disease; current status.
复制标题
脑血管疾病的抗凝治疗；
DOI：
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发表时间：
1958
影响因子：
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通讯作者：
J. Whisnant
中科院分区：
文献类型：
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作者：
C. Millikan;R. Siekert;J. Whisnant
应用肝素、双香豆酸乙酯和双羟基香豆素抗凝治疗317例有脑血管疾病表现的患者。一组94例患者被归类为椎骨-基底系统间歇性功能不全，其中90例患者在药物的抗凝作用通过实验室测试得到证实后，发作完全停止。一组107例不可逆性椎基底动脉血栓患者在抗凝治疗中死亡率仅为8%，而31例未接受抗凝治疗的类似患者的死亡率为58%。85例颈动脉系统间歇性功能不全患者接受抗凝治疗，其中82例特征性发作停止。在一组31例颈内动脉血栓形成进展积极的患者中，只有6%的患者发展为偏瘫，而在17例未接受抗凝剂治疗的类似患者中，这一比例为35%。抗凝治疗是预防性的，而不是重建性的，但确实有利于改变这四种类型患者的脑血管疾病的自然史。
Anticoagulant therapy with heparin, ethyl biscoumacetate, and bishydroxycoumarin was used in 317 patients with manifestations of cerebral vascular disease. A group of 94 patients were classified as having intermittent insufficiency in the vertebral-basilar system, and in 90 of these the attacks stopped completely soon after the anticoagulant effect of the drugs became demonstrable by laboratory tests. A group of 107 patients with irreversible vertebral-basilar thrombosis had a mortality rate of only 8% on anticoagulant therapy as compared with a rate of 58% reported in 31 similar patients who did not receive anticoagulants. A group of 85 patients with intermittent insufficiency in the carotid system were treated with anticoagulants, and in 82 the characteristic attacks were stopped. A group of 31 patients with actively advancing carotid thrombosis went on to hemiplegia in only 6 % of the cases, as compared with 35 % of a reported series of 17 similar patients who did not receive anticoagulants. Anticoagulant treatment is preventive rather than reconstructive, but does alter favorably the natural history of cerebral vascular disease in patients of these four types.