Enantioselective synthesis of isoindolines: an organocatalyzed domino process based On the aza-Morita-Baylis-Hillman reaction.
Enantioselective synthesis of isoindolines: an organocatalyzed domino process based On the aza-Morita-Baylis-Hillman reaction.
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DOI：
10.1002/anie.201004547
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发表时间：
2010-12
影响因子：
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通讯作者：
S. Takizawa;N. Inoue;S. Hirata;H. Sasai
中科院分区：
文献类型：
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作者：
S. Takizawa;N. Inoue;S. Hirata;H. Sasai
有机催化的不对称多米诺过程是一种非常有吸引力的方法，因为它能够在温和的反应条件下，在两个或多个步骤中在一个操作中从容易获得的底物构建复杂的手性分子。这些反应可以节省时间和通常用于分离或纯化合成中间体所需的化学品。此外，不必担心产物的金属污染，因为有机催化剂不含有毒或昂贵的金属。手性仲胺介导的有机催化不对称多米诺反应实例
The organocatalytic asymmetric domino process is a veryattractive method because of its ability to construct complexchiral molecules from readily available substrates under mildreaction conditions in two or more steps in a single operation.These reactions can save the time and the chemicals usuallyrequired for isolation or purification of the synthetic inter-mediates.Inaddition,noconcernformetalcontamination of the products is necessarybecause organocatalysts do not containtoxic or expensive metals. Examples oforganocatalytic asymmetric domino reac-tions mediated by chiral secondaryamines