TRANSDUCTION PROPERTIES OF TRACHEAL STRETCH RECEPTORS
TRANSDUCTION PROPERTIES OF TRACHEAL STRETCH RECEPTORS
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DOI：
10.1113/jphysiol.1976.sp011428
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发表时间：
1976-01-01
影响因子：
5.5
通讯作者：
WISE, JCM
中科院分区：
文献类型：
--
作者：
BARTLETT, D;SANTAMBROGIO, G;WISE, JCM
本文用单纤维迷走神经传入记录技术，研究了犬离体原位气管段慢适应牵张感受器的行为。对正、负稳态和振荡跨壁压的响应进行了研究。在研究的受体中，78%在静息气管容积下具有张力活性; 90%对正透壁压的反应比对负透壁压的反应更明显。在压力振荡过程中，大多数的受体有一个更高的放电频率在任何给定的压力在压力波的上升阶段比在静态条件下相同的压力。在随后的大部分压力下降到零的放电频率低于相应的静态值。放电频率导致跨壁压。随着振荡频率的增加，与静态响应的差异增加（dP/dt灵敏度），特别是在压力振荡的上升分支期间（整流行为）。在少数感受器中，放电频率滞后于跨壁压或与其同相（无环路模式）。在3例中，同一受体在正压力振荡时表现出dP/dt敏感性，但在负压力振荡时放电频率滞后于压力。负压条件下dP/dt敏感性的缺乏显然并不代表这些受体的固有特性，而是反映了它们在气道壁内机械排列的某些方面。这些模式的反应进行了讨论的内在和外在的受体的特性。牵张感受器行为的生理意义也被考虑。
Using single fiber vagal afferent recording, the behavior of slowly adapting stretch receptors located in an isolated, in situ, segment of the trachea in dogs was studied. Responses to positive and negative steady and oscillating transmural pressures were investigated. Of the receptors studied, 78% were tonically active at resting tracheal volume; 90% showed a more pronounced response to positive than to negative transmural pressures. During pressure oscillations, the majority of the receptors had a higher discharge frequency at any given pressure during the ascending phase of the pressure wave than at the same pressure under static conditions. During most of the ensuing descent of pressure toward zero the discharge frequency was lower than the corresponding static value. Discharge frequency led transmural pressure. With increasing frequency of oscillation the differences from the static responses increased (dP/dt sensitivity), especially during the ascending limb of the pressure oscillation (rectifying behavior). In a small number of receptors, discharge frequency lagged behind transmural pressure or was in phase with it (no loop pattern). In 3 cases the same receptor exhibited dP/dt sensitivity during positive pressure oscillations but discharge frequency lagged behind pressure during negative oscillations. The lack of dP/dt sensitivity exhibited under negative pressure conditions apparently does not represent an intrinsic property of these receptors but reflects some aspect of their mechanical arrangement whithin the airway wall. These patterns of response are discussed in terms of intrinsic and extrinsic characteristics of the receptors. The physiological implications of stretch receptor behavior are also considered.